The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.
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Children Witness Nearly Ten Percent of US Violent Deaths and Suicides
A CDC surveillance analysis reveals that most child-witnessed fatal events occur in homes and involve firearms or domestic conflict.
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Medicaid Expansion Linked to Lower Mortality in Young Adult Dialysis Patients
A cohort study shows a 1.8 percentage point drop in one-year mortality for young adults starting dialysis after Medicaid expansion.
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Redlining and Modern Loan Denials Drive Chicago Firearm Homicides
Historical housing maps and current economic discrimination act as independent, measurable factors in urban firearm violence disparities.
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Dihydroartemisinin-Piperaquine Reduces Early Plasmodium vivax Recurrence Compared With Chloroquine
A randomized trial in Brazil shows dihydroartemisinin-piperaquine effectively prevents early malaria recurrence when primaquine is delayed.
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Early Cystography After Bladder Repair Reduces Catheter Time and Infections
Imaging within seven days of traumatic bladder repair safely shortens catheterization and lowers infection rates without missing leaks.
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Single Sigmoidoscopy Reduces Male Colorectal Cancer Death at 23 Years
A Norwegian trial shows a single screening sigmoidoscopy provides long-term protection for men, but mortality benefits are absent in women.
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Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.
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Digoxin Reduces Heart Failure Risk in Rheumatic Heart Disease
A randomized trial in India shows low-dose digoxin decreases the composite risk of death or worsening heart failure by 18 percent.
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Nurse-Led School CPR Program Multiplies Community Training Reach
Students using low-cost manikins trained an average of 2.4 family members, significantly expanding the pool of potential bystanders.
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Transradial Access Does Not Increase Radiation in Aneurysm Treatment
A comparative study finds no significant difference in radiation dose between radial and femoral routes for endovascular repair.
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Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
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Low-Dose Digoxin Fails to Reduce Heart Failure Events in Randomized Trial
A study of 1,001 patients found targeting low serum concentrations did not significantly lower mortality or urgent hospital visits.
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Early Magnesium Sulfate Linked to Lower Mortality in Pneumonia
A retrospective analysis of 9,203 ICU patients suggests early intravenous magnesium may reduce 30-day mortality risk by 16 percent.
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Resident Response Vehicles Increase Exposure to High-Acuity Prehospital Care
A five-year study shows dedicated field vehicles provide residents with over 1,300 cardiac arrests and 2,000 medical control consults.
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Quality Improvement Shortens Time to Antibiotics in Pediatric Intestinal Failure
Multidisciplinary interventions reduced median cephalosporin delivery time by 58% for children with suspected central line infections.
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Glofitamab Shows High Response Rates in Refractory Aggressive B-Cell Lymphoma
Real-world data link baseline CD4+ effector T cells and early CD8+ expansion to improved outcomes with bispecific antibody therapy.
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Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.
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Biliopancreatic Diversion Shows Durable Weight Loss but High Long-Term Morbidity
A 50-year cohort study finds universal diabetes remission and sustained weight loss alongside an 86% nutritional complication rate.
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Paramedic Discharge Protocols Reduce Call Times but Remain Underutilized
Prehospital discharge for resolved seizures and hypoglycemia cuts call duration by half compared to emergency department transport.
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IVC to Aorta Ratio Tracks Fluid Response but Lacks Clinical Correlation
Ultrasound metrics of the inferior vena cava change after fluid boluses in pediatric shock but do not align with heart rate or shock index.
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CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.
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Chronic Cocaine Use Linked to Rare Baló-Like Concentric Leukoencephalopathy
Two cases in Italy reveal a specific pattern of inflammatory demyelination that responds to steroids but requires cocaine abstinence.
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CFTR Modulators Reduce 8-Year Mortality Risk by 7.2% in Cystic Fibrosis
A registry-based cohort study of 25,103 individuals shows a 66% reduction in the hazard of death following modulator initiation.