Most Common Mental Disorder Interventions Lack Robust Evidence
A systematic review of Cochrane data reveals that less than a quarter of interventions for common mental disorders have high or moderate quality evide
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Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD…
General Medicine Daily Digest — May 20, 2026
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Catch up with your daily audio briefing on the clinical updates that matter most.
All of Us Program Links 14 Years of Wearable Data to Clinical Records
A massive dataset connects Fitbit metrics from 59,000 participants to genomics and electronic health records for longitudinal research.
IDH1 Mutations in Prostate Cancer Link High Stage/Grade to Favorable Outcomes
A retrospective analysis identifies IDH1 mutations as a marker for improved survival in prostate cancer, despite aggressive initial presentation.
Teriparatide Plus Zoledronic Acid Does Not Reduce Fracture Risk in Adults with OI
A randomized trial found that while combination therapy increased bone mineral density, it did not lower fracture incidence.
Trial Watch
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Dose-Sparing Polio Vaccine Matches Full-Dose Immunogenicity and Safety in Infants
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Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
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Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
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Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
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Ensitrelvir Reduces COVID-19 Incidence by 6.1% in Household Contacts
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Abatacept Reduces Rheumatoid Arthritis Progression in Seropositive Palindromic Rheumatism
New Guidelines
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SCCM and ESICM launch 2026 guideline for Sepsis and Septic Shock Management
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AHA and ACC launch 2026 guideline for Acute Pulmonary Embolism in Adults
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AHA and ASA launch 2026 guideline for Acute Ischemic Stroke management
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ACEP launches 2025 clinical policy for Endotracheal Intubation in the Emergency Department
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LANCETP launches 2025 guideline for Algorithmic Treatment of Schizophrenia
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AA and SNMMI launch 2025 guideline for Amyloid and Tau PET Appropriate Use Criteria
Latest
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Pre-SRS PD-1 Inhibitor Use Linked to Increased Neurological Deficits, Mortality
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DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
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Younger Brain Age Buffers Cognitive Impact of Tau Pathology
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4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
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POGO Score Shows Limited Diagnostic Value in Pediatric Videolaryngoscopy
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Semantic-Metacognitive Therapy Improves Naming in Semantic Variant PPA