The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
Earlier
24 stories-
CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.
-
Chronic Cocaine Use Linked to Rare Baló-Like Concentric Leukoencephalopathy
Two cases in Italy reveal a specific pattern of inflammatory demyelination that responds to steroids but requires cocaine abstinence.
-
CFTR Modulators Reduce 8-Year Mortality Risk by 7.2% in Cystic Fibrosis
A registry-based cohort study of 25,103 individuals shows a 66% reduction in the hazard of death following modulator initiation.
-
Digitalis Reduces Worsening Heart Failure Events in Large Meta-Analysis
A study of 9,013 patients shows digitalis glycosides lower the risk of worsening heart failure events without affecting mortality.
-
Ruxolitinib Resolves Severe Diarrhea Following BCMA-Targeted CAR T-Cell Therapy
A case series suggests JAK inhibition may mitigate the high mortality associated with immune-mediated enterocolitis in multiple myeloma.
-
NXT007 Reaches Nonhemophilic Factor VIII Levels in Severe Hemophilia A
A phase 1/2 trial shows monthly subcutaneous NXT007 achieves factor activity above 40 IU/dL and eliminates bleeds at higher doses.
-
Carotid Doppler Parameters Predict Return of Spontaneous Circulation During CPR
Waveform-derived metrics like velocity time integral show high predictive value for resuscitation success in emergency department patients.
-
Photon-Counting CT Improves Pulmonary Artery Visibility at Lower Radiation Doses
Ultra-high-resolution imaging increases diagnostic confidence and vascular attenuation compared to standard energy-integrating detectors.
-
Propofol Reduces Long-Term Water Contamination Compared to Sevoflurane
A modeling study finds sevoflurane leads to irreversible accumulation of trifluoroacetic acid while propofol residues remain biodegradable.
-
Penetrating Brain Injury Mortality Reaches 42% While Prophylaxis Compliance Lags
Despite high mortality, 70% of survivors achieve favorable outcomes, though adherence to antibiotic and seizure protocols remains low.
-
Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
-
SMART Model Matches Radiologists in Differentiating New Lung Malignancies
A CT-based tool using semantic features like emphysema and spiculation helps distinguish second primary lung cancers from metastases.
-
SSPOP Gene Mutations Linked to Pediatric Epilepsy and Developmental Delay
Researchers identify pathogenic variants in a presumed pseudogene, expanding the diagnostic landscape for unexplained seizure disorders.
-
CT Metrics Predict Benralizumab Response in Severe Asthma
Quantitative imaging of small airway disease and sinus opacification identifies responders more accurately than blood eosinophil counts.
-
Automated Software Identifies Hundreds of Patients Lost to Aneurysm Follow-Up
Natural language processing of 7.5 million imaging reports captured 492 new patients and generated 47 surgical repairs.
-
Perinatal Cash Transfers Linked to 32% Drop in Infant Maltreatment Reports
A study of Flint's Rx Kids program shows unconditional cash support significantly reduces child protective services investigations.
-
Preexisting Mental Disorders Increase Mortality After Spinal Injury
A cohort study finds younger patients with dual diagnoses face a 17-fold higher mortality risk following traumatic spinal injury.
-
Emergency Eye Calls Often Mask Acute Stroke and TIA
A Danish cohort study reveals that 7.4% of patients hospitalized for primary ocular complaints were ultimately diagnosed with a stroke.
-
Low Cardiac Index During Hypotension Increases Acute Kidney Injury Risk
A study of 1,272 cardiac surgery patients finds that hypotension only correlates with renal injury when cardiac index falls below 2.
-
Rapid Inter-Temporal Seizure Spread Linked to Poor Surgical Outcomes
Deep learning analysis of 275 seizures shows that extensive cortical involvement and rapid propagation correlate with surgical failure.
-
Platelet Transfusion Linked to Higher Mortality in Sepsis Patients
A retrospective study finds transfusions increase ICU stay and thrombosis risk while failing to raise counts in half of septic patients.
-
Psychological Factors Predict High-Impact Chronic Pain in Sickle Cell Disease
A prospective study of 90 patients shows that pain catastrophizing and low self-efficacy correlate with sustained functional impairment.
-
C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.
-
Prophylactic Antiemetics Fail to Reduce Opioid-Induced Nausea in Prehospital Trauma
A prospective study of 205 HEMS patients shows no benefit for routine intravenous ondansetron or isopropanol aromatherapy.