The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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24 stories-
Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.
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Pediatric Fibula Harvest Carries High Risk of Ankle Valgus and Nerve Palsy
A 27-year review identifies the Age-Residual Fibula Index as a key predictor for donor-site morbidity in skeletally immature patients.
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Deucravacitinib Modulates Over 2,500 Genes in Systemic Lupus Erythematosus
Transcriptomic analysis shows TYK2 inhibition reverses myeloid dysregulation and increases regulatory T-cell populations in patients with lupus.
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Accelerated Deep TMS Protocols Show High Remission Rates in Depression
A randomized trial finds that 10-day accelerated deep TMS protocols achieve 42% to 50% remission rates, exceeding pharmacotherapy alone.
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Breast GPA Predicts Intracranial Progression and Survival in Breast Cancer
A large cohort study links local brain control to overall survival, identifying tumor subtype and performance status as key predictors.
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Testosterone Therapy Improves Sexual Function After Radical Prostatectomy
A phase 2 trial shows 12 weeks of testosterone cypionate enhances libido and body composition without triggering biochemical recurrence.
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Children Witness Nearly Ten Percent of US Violent Deaths and Suicides
A CDC surveillance analysis reveals that most child-witnessed fatal events occur in homes and involve firearms or domestic conflict.
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Genetic Risk and Social Deprivation Drive Regional Drug Use Clusters
A Swedish study of 5,983 districts finds that family genetic risk and community deprivation explain most geographic variation in addiction.
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Medicaid Expansion Linked to Lower Mortality in Young Adult Dialysis Patients
A cohort study shows a 1.8 percentage point drop in one-year mortality for young adults starting dialysis after Medicaid expansion.
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Deep Learning Model Predicts Ki-67 Status and Metastatic Risk via Ultrasound
A multicenter study shows a noninvasive model identifies high-risk breast cancer features and predicts early recurrence with high accuracy.
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Reduced Visit Pressure Increases Diagnosis Rates in Primary Care
A study of 191,269 visits shows that relieving schedule constraints allows physicians to address more new and chronic clinical issues.
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Galectin-3 Inhibition Prevents Excitatory Synapse Loss in Murine Neuroinflammation Models
Targeting microglial Galectin-3 preserves hippocampal gamma power and cognitive function by stopping the selective engulfment of synapses.
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ACL Reconstruction Triples 20-Year Risk of Total Knee Arthroplasty
A study of 135,881 patients shows a 2.44% absolute risk of knee replacement two decades after surgery, rising with meniscal involvement.
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Redlining and Modern Loan Denials Drive Chicago Firearm Homicides
Historical housing maps and current economic discrimination act as independent, measurable factors in urban firearm violence disparities.
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Adipose Blocks Stored at -80 °C Maintain Multipotent Cell Viability
A protocol using commercial freezers and rapid thawing preserves 88% of stromal vascular fraction cells for up to four months.
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CSF Tau Biomarkers Associate With Cognitive Impairment in ALS
Elevated cerebrospinal fluid tau levels correlate with cognitive deficits in ALS, though postmortem TDP-43 burden remains a stronger driver.
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Dihydroartemisinin-Piperaquine Reduces Early Plasmodium vivax Recurrence Compared With Chloroquine
A randomized trial in Brazil shows dihydroartemisinin-piperaquine effectively prevents early malaria recurrence when primaquine is delayed.
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Validated 33-Item Instrument Quantifies Patient Misconceptions Regarding Hospice Care
The Hospice Perceptions Instrument identifies specific barriers to enrollment, including myths about eligibility and service quality.
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Early Cystography After Bladder Repair Reduces Catheter Time and Infections
Imaging within seven days of traumatic bladder repair safely shortens catheterization and lowers infection rates without missing leaks.
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Dementia With Lewy Bodies Incidence Rises Sharply After Age 65
A meta-analysis of population-based studies reveals significant age and sex disparities in dementia with Lewy bodies epidemiology.
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Single Sigmoidoscopy Reduces Male Colorectal Cancer Death at 23 Years
A Norwegian trial shows a single screening sigmoidoscopy provides long-term protection for men, but mortality benefits are absent in women.
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Beti-cel Gene Therapy Sustains Transfusion Independence for Up to Ten Years
Long-term data show 90.2% of phase 3 patients achieved transfusion independence with stable hemoglobin and improved iron homeostasis.
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Palliative Care Reduces Hospital Death Risk in Multiple Sclerosis
A large cohort study finds neurology oversight drops sharply before death, while rural patients face higher hospital mortality rates.
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Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.