Acetate Attenuates Microglial Inflammation in Traumatic Brain Injury Model, Not Sepsis
Physiological doses of the gut metabolite acetate reduced inflammatory markers in an in vitro TBI model, but not in a sepsis model.
Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
Autonomic Burden Linked to Cognitive Fluctuations in Lewy Body Dementia
A longitudinal study finds autonomic symptom severity correlates with neuropsychiatric burden and reduced caregiver quality of life.
Anterior Temporal Atrophy Precedes Semantic Dementia Symptoms by Five Years
Large-scale MRI analysis identifies a prolonged prodromal phase and quantifies the prevalence of incidental anterior temporal lobe loss.
Amateur Soccer Heading Linked to Acute Elevations in Neural Damage Biomarkers
A prospective study found that heading in amateur soccer acutely increases blood levels of p-tau217 and S100B, with dose-response relationships.
Four Clinical Trajectories Identify Distinct Outcomes in Acute Respiratory Failure
A multi-cohort analysis reveals predictable 14-day courses for patients with persistent acute hypoxemic respiratory failure.
Cervical Spinal Cord Injury Linked to Higher Depression Risk Than Lower-Level Injuries
A nationwide cohort study reveals patients with cervical SCI face a significantly elevated risk of depression compared to those with thoracic/lumbar.
Exome Sequencing Identifies Genetic Links in Persistent Tachypnea of Infancy
Comprehensive genetic testing reveals that persistent tachypnea of infancy often associates with underlying neurodevelopmental conditions.
Real-World Data Predicts Long-Term Poor Outcomes in Clinical High-Risk Psychosis
A new model identifies individuals at clinical high risk for psychosis who face diverse long-term adverse events, including hospitalization and suicid
MEG Reveals Specific Brain and Autonomic Changes in PTSD Affective Processing
Electrophysiological and heart rhythm markers identify altered affective processing in service members with post-traumatic stress disorder.
CircPCMTD1 Peptide Regulates DNA Damage Response in BCR/ABL1-Positive Leukemias
A newly characterized circular RNA and its peptide product modulate genotoxic stress tolerance, offering a potential therapeutic target.
Adenoviral Protein Reactivity Linked to Guillain-Barré Syndrome After COVID-19
Patients with post-infection or post-vaccination GBS show heightened antibody responses to adenoviruses, suggesting a shared trigger.