Pre-SRS PD-1 Inhibitor Use Linked to Increased Neurological Deficits, Mortality
A multi-institutional study suggests administering PD-1 inhibitors before stereotactic radiosurgery in glioma patients may worsen outcomes.
Most Common Mental Disorder Interventions Lack Robust Evidence
A systematic review of Cochrane data reveals that less than a quarter of interventions for common mental disorders have high or moderate quality evide
DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
A new study identifies dihydroorotate dehydrogenase (DHODH) as a metabolic vulnerability in B-ALL cells with active signaling.
Younger Brain Age Buffers Cognitive Impact of Tau Pathology
Structural brain integrity, but not education level, modifies the link between p-tau217 and cognitive performance in older adults.
4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
POGO Score Shows Limited Diagnostic Value in Pediatric Videolaryngoscopy
A study of 904 pediatric intubations found the POGO score performed poorly in classifying difficult airways and predicting adverse events.
Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD.
Semantic-Metacognitive Therapy Improves Naming in Semantic Variant PPA
A single-case experimental study shows specific speech therapy can improve naming performance in individuals with semantic variant primary.
Abortion Bans Linked to Shifts in Spontaneous Abortion Management
A study of commercially insured individuals finds state-level abortion bans are associated with increased expectant management and misoprostol-only.
POD1 Prolactin Levels Predict Long-Term Outcomes After Prolactinoma Resection
Postoperative day 1 prolactin levels help stratify risk for hyperprolactinemia rebound and recurrence, especially with prior dopamine agonist use.
Deep Learning Model Predicts Lung Cancer Risk from Single CT Scan in Asian Cohort
Sybil, an AI model, shows robust performance in predicting future lung cancer risk, including in never-smokers, using low-dose CT.
Global Psychiatry Congress Reveals Gender, Age, Geographic Representation Patterns
Analysis of the 25th World Congress of Psychiatry highlights attendee demographics and presenter contributions by gender and country income.