The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
This week
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Memory Deficits Persist in Multiple Sclerosis Despite Preserved Processing Speed
Modern treatment eras show a shift where cognitive slowing is no longer the primary deficit in relapsing-remitting multiple sclerosis.
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Current Late-Life Depression Linked to Specific Right Hippocampal Subregion Volume Reductions
A new study details distinct hippocampal volume alterations in currently depressed older adults, differentiating them from remitted states.
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REM Sleep EEG Slowing Linked to Cholinergic Denervation in Older Adults
Specific REM sleep electroencephalogram patterns correlate with brain cholinergic integrity, potentially aiding early diagnosis in Alzheimer's disease
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Maternal Fasting in Mice Induces Schizophrenia-Related Phenotypes
A mouse model links transient fasting during early gestation to epigenetic changes and altered neural circuitry in offspring.
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Focal Brain Lesions Pinpoint Common OCD Network and Treatment Targets
A systematic review identifies a shared brain network in lesional and primary OCD, aligning with neuroimaging and neuromodulation sites.
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Habenula Hyperconnectivity in Autism Linked to Social Deficits
A large-scale rs-fMRI study identifies specific habenula functional connectivity alterations in autistic individuals, impacting social motivation…
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Age, Sex, and Initial Diagnosis Shape Mental Disorder Trajectories
A large Danish cohort study details how initial diagnosis, age, and sex influence diagnostic shifts and healthcare utilization.
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FDA-Approved Therapies and Multidisciplinary Care Extend Survival in ALS
New clinical data highlight the role of genetic testing and targeted therapies in managing progressive motor neuron degeneration.
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FGF14 Repeat Expansions Identified in Patients with Parkinson's Disease
Long-read sequencing reveals that a genetic variant linked to ataxia also occurs in patients meeting clinical criteria for Parkinson's.
Earlier
15 stories-
Cerebrotendinous Xanthomatosis Drives Recurrent Stroke After PFO Closure
A 23-year-old's recurrent M1 occlusion reveals how metabolic drivers of premature atherosclerosis can mimic or coexist with structural defects.
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Accelerated Deep TMS Protocols Show High Remission Rates in Depression
A randomized trial finds that 10-day accelerated deep TMS protocols achieve 42% to 50% remission rates, exceeding pharmacotherapy alone.
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Testosterone Therapy Improves Sexual Function After Radical Prostatectomy
A phase 2 trial shows 12 weeks of testosterone cypionate enhances libido and body composition without triggering biochemical recurrence.
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Children Witness Nearly Ten Percent of US Violent Deaths and Suicides
A CDC surveillance analysis reveals that most child-witnessed fatal events occur in homes and involve firearms or domestic conflict.
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Genetic Risk and Social Deprivation Drive Regional Drug Use Clusters
A Swedish study of 5,983 districts finds that family genetic risk and community deprivation explain most geographic variation in addiction.
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Reduced Visit Pressure Increases Diagnosis Rates in Primary Care
A study of 191,269 visits shows that relieving schedule constraints allows physicians to address more new and chronic clinical issues.
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Galectin-3 Inhibition Prevents Excitatory Synapse Loss in Murine Neuroinflammation Models
Targeting microglial Galectin-3 preserves hippocampal gamma power and cognitive function by stopping the selective engulfment of synapses.
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Redlining and Modern Loan Denials Drive Chicago Firearm Homicides
Historical housing maps and current economic discrimination act as independent, measurable factors in urban firearm violence disparities.
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CSF Tau Biomarkers Associate With Cognitive Impairment in ALS
Elevated cerebrospinal fluid tau levels correlate with cognitive deficits in ALS, though postmortem TDP-43 burden remains a stronger driver.
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Dementia With Lewy Bodies Incidence Rises Sharply After Age 65
A meta-analysis of population-based studies reveals significant age and sex disparities in dementia with Lewy bodies epidemiology.
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Palliative Care Reduces Hospital Death Risk in Multiple Sclerosis
A large cohort study finds neurology oversight drops sharply before death, while rural patients face higher hospital mortality rates.
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Nuclear Membrane Disruption Precedes Cytoplasmic Tau in Anti-IgLON5 Disease
Autopsy and in vitro data show that antibody binding triggers nuclear invaginations and serine 422 phosphorylation before tau aggregates.
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Comorbidity Drives Genetic Overlap Between Anxiety and Major Depression
Excluding comorbid cases reveals that isolated anxiety and depression are more genetically distinct than previously recognized.
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Subthalamic Signal Propagation Predicts Parkinsonian Motor State
Movement-related high-frequency oscillations propagate along the inferior-superior axis, correlating with levodopa response.
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Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.