The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
This week
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Neuroimaging Biotypes May Guide MDD Treatment, Improve Remission
Functional MRI-derived circuit profiles could personalize major depressive disorder therapy, potentially doubling remission rates.
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Apelin Mediates Exercise's Antidepressant Effects via Hippocampal NMDA Receptors
A muscle-derived protein, apelin, links physical activity to improved mood and neuroplasticity through a specific brain signaling pathway.
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Three Genetic Loci Modify Risk and Onset of Inherited Alzheimer's Disease
Specific genetic variants influence disease risk and age of dementia onset in autosomal dominant Alzheimer's disease.
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Fentanyl Differentially Modulates Dopamine Patterns, Impairing Reward Seeking in Mice
Acute fentanyl administration simultaneously increases tonic dopamine while reducing phasic dopamine responses to non-drug reward cues.
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ICU Caregiver Financial Strain Linked to Psychological Distress, Medical Mistrust
A study of 97 ICU caregivers found that over 60% reported difficulty paying for care, correlating with increased anxiety, depression, PTSD, and decisi
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Secreted GPNMB Drives Alpha-Synuclein Spread in Parkinson's Disease
A new study identifies a microglial-neuronal feedback loop involving GPNMB that exacerbates alpha-synuclein pathology, offering a therapeutic target.
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Skin Biopsy Distinguishes Body-First from Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein signatures and seeding activity identify divergent pathological origins and autonomic denervation patterns.
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TES Criteria Show Low Accuracy for CTE-NC Diagnosis
A study of 1,038 brain bank cases reveals that traumatic encephalopathy syndrome criteria poorly predict postmortem chronic traumatic encephalopathy.
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Intracranial Stimulation Prevents Attentional Lapses in Children
A new study identifies a real-time neural signature for attentional control, enabling targeted intervention to improve attention shifts.
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Recent Trauma Exposure Linked to Increased V1 Thickness, Independent of PTSD Symptoms
A two-sample study identifies greater V1 thickness in recently trauma-exposed individuals, a finding distinct from PTSD symptom severity.
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Hippocampal Lesions Reduce Visual Working Memory Precision in Epilepsy Patients
Postoperative hippocampal damage selectively degrades memory quality rather than quantity, offering a marker for functional monitoring.
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Reduced ULK1 Links Impaired Cellular Clearance to Alzheimer's Pathology
Lower levels of ULK1 correlate with Alzheimer's disease, and its upregulation improves pathology and cognition in animal models.
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Thalamic Connections to Medial Prefrontal Cortex Predict Impulsivity
A new study links specific thalamic subregions, defined by cortical connectivity, to individual differences in delay discounting.
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Thalamic-MPFC Connectivity Linked to Individual Differences in Impulsivity
A new study identifies specific thalamic subregions connected to the medial prefrontal cortex as structural correlates of delay discounting.
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Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.
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Nitrous Oxide Addiction Linked to DCN-VTA Circuit, AMPA Receptor Potentiation
A new study identifies how nitrous oxide directly enhances AMPA receptor function in the DCN-VTA circuit, mediating its rewarding effects.
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Nitrous Oxide Reward Driven by DCN-VTA Circuit, AMPA Receptor Potentiation
A new study in animal models identifies the specific neural circuit and molecular mechanism underlying nitrous oxide's rewarding effects.
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GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
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Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.
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Macaque V1 Neuron Activity Links Internal States to Reaction Time, Perceptual Choice
New research in macaque monkeys reveals how primary visual cortex neuron membrane potential dynamically influences visual task performance.
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Familial Brain Pattern Similarity Links to Psychotic Disorder Risk in Offspring
A new index quantifying cortical thickness similarity between parents with psychosis and their offspring correlates with psychiatric diagnoses.
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Acute Kidney Injury Predicts Increased Risk of Stroke and Dementia
A meta-analysis of 11 million patients links acute renal insults to a 35% higher stroke risk and nearly fivefold 90-day poststroke mortality.
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Intracranial Recordings Map Immediate and Distal Neural Responses to Magnetic Stimulation
A review of human and primate data shows single-pulse TMS excites neurons in 2 milliseconds and modulates networks for up to 40 minutes.
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Digital Interventions Improve Eating Disorder Symptoms and Comorbid Mental Health
A meta-analysis of 36 trials shows digital tools offer consistent, durable benefits for core eating disorder symptoms and associated mental health con