FGF14 Repeat Expansions Identified in Patients with Parkinson's Disease
Long-read sequencing reveals that a genetic variant linked to ataxia also occurs in patients meeting clinical criteria for Parkinson's.
Acupuncture and Herbal Formula Improve Visual Acuity in Optic Atrophy
Combining acupuncture with Jieyu Huoxue Formula reduces blood viscosity and increases peak systolic velocity to protect the optic nerve.
Cerebrotendinous Xanthomatosis Drives Recurrent Stroke After PFO Closure
A 23-year-old's recurrent M1 occlusion reveals how metabolic drivers of premature atherosclerosis can mimic or coexist with structural defects.
Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.
Breast GPA Predicts Intracranial Progression and Survival in Breast Cancer
A large cohort study links local brain control to overall survival, identifying tumor subtype and performance status as key predictors.
Galectin-3 Inhibition Prevents Excitatory Synapse Loss in Murine Neuroinflammation Models
Targeting microglial Galectin-3 preserves hippocampal gamma power and cognitive function by stopping the selective engulfment of synapses.
CSF Tau Biomarkers Associate With Cognitive Impairment in ALS
Elevated cerebrospinal fluid tau levels correlate with cognitive deficits in ALS, though postmortem TDP-43 burden remains a stronger driver.
Dementia With Lewy Bodies Incidence Rises Sharply After Age 65
A meta-analysis of population-based studies reveals significant age and sex disparities in dementia with Lewy bodies epidemiology.
Palliative Care Reduces Hospital Death Risk in Multiple Sclerosis
A large cohort study finds neurology oversight drops sharply before death, while rural patients face higher hospital mortality rates.
Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.
Nuclear Membrane Disruption Precedes Cytoplasmic Tau in Anti-IgLON5 Disease
Autopsy and in vitro data show that antibody binding triggers nuclear invaginations and serine 422 phosphorylation before tau aggregates.
Transradial Access Does Not Increase Radiation in Aneurysm Treatment
A comparative study finds no significant difference in radiation dose between radial and femoral routes for endovascular repair.