Subthalamic Signal Propagation Predicts Parkinsonian Motor State
Movement-related high-frequency oscillations propagate along the inferior-superior axis, correlating with levodopa response.
Neurosurgeons Disagree on Resectability in Recurrent Glioblastoma Trial
A post-hoc analysis reveals low inter-rater agreement on surgical feasibility and no link between surgeon consensus and survival.
Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.
Early Radiographic Response Poorly Predicts Local Control in Brain Metastases
A large cohort study finds that stable disease and partial response carry similar recurrence risks after radiation therapy.
Chronic Cocaine Use Linked to Rare Baló-Like Concentric Leukoencephalopathy
Two cases in Italy reveal a specific pattern of inflammatory demyelination that responds to steroids but requires cocaine abstinence.
Arterial Netrin-4 Maintains Adult Sympathetic Neurons in Mice
Intracranial arteries provide a trophic niche that prevents age-related neuronal attrition through a non-inflammatory death pathway.
Long-Read Sequencing Resolves Atypical Facioscapulohumeral Dystrophy Loci
High-resolution sequencing identifies complex structural variants in the 1% to 2% of patients who lack standard genetic markers.
Selective HDAC6 Inhibition Restores Axonal Transport in Preclinical ALS Models
A brain-penetrant small molecule improves motor function and reduces TDP-43 pathology in animal and human cellular models of neurodegeneration.
Amygdala Damage Does Not Impair Intrinsic Motivation to Empathize
Patients with focal amygdala lesions maintain a normal drive to engage in empathic encounters despite deficits in emotional recognition.
Gamma Knife Surgery Provides Durable Control of Vestibular Schwannoma
A 30-year study shows true tumor progression is rare after 10 years, supporting reduced imaging for patients stable at the 5-year mark.
BRAF V600E Mutation Predicts Early Recurrence in Rathke Cleft Cysts
A retrospective analysis of 383 sellar lesions suggests BRAF-positive cysts behave like papillary craniopharyngiomas and require reclassification.