DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
A new study identifies dihydroorotate dehydrogenase (DHODH) as a metabolic vulnerability in B-ALL cells with active signaling.
Acetate Attenuates Microglial Inflammation in Traumatic Brain Injury Model, Not Sepsis
Physiological doses of the gut metabolite acetate reduced inflammatory markers in an in vitro TBI model, but not in a sepsis model.
CircPCMTD1 Peptide Regulates DNA Damage Response in BCR/ABL1-Positive Leukemias
A newly characterized circular RNA and its peptide product modulate genotoxic stress tolerance, offering a potential therapeutic target.
PSMD1 Inhibition via LNPs Reduces Myeloma Growth, Overcomes Resistance
Targeting the proteasome subunit PSMD1 with siRNA delivered by lipid nanoparticles shows efficacy in multiple myeloma models.
Fibrin Binding Explains Reduced Circulating Myosin After Trauma
Direct binding of skeletal muscle myosin to fibrin clots may clarify its role in trauma-induced coagulopathy and observed plasma level changes.
Cutamesine Mitigates Hippocampal Damage in In Vitro Ischemia Models
A sigma-1 receptor agonist reduced neuronal cell death and cellular stress markers in rat hippocampal slices exposed to oxygen-glucose deprivation.
Military Blood Supply Insufficient for Large-Scale Combat Operations
Simulation reveals current Forward Resuscitative Surgical Detachment blood strategies, even with walking blood banks, fail rapidly under high casualty
NPM1-Mutated AML: Nuclear Condensates Drive HOX/MEIS1 Expression, Inform Menin Inhibitor Action
New research clarifies how mutant NPM1 forms nuclear condensates, sustaining oncogenic transcription and explaining menin inhibitor efficacy.
Cerebellar Disinhibitory Circuit Controls Motor Learning Signals
New research in mice reveals how synchronized climbing fiber activity selectively gates error signals to enable adaptive motor learning.
Nitrous Oxide Addiction Linked to DCN-VTA Circuit, AMPA Receptor Potentiation
A new study identifies how nitrous oxide directly enhances AMPA receptor function in the DCN-VTA circuit, mediating its rewarding effects.
Nitrous Oxide Reward Driven by DCN-VTA Circuit, AMPA Receptor Potentiation
A new study in animal models identifies the specific neural circuit and molecular mechanism underlying nitrous oxide's rewarding effects.
Urinary Nanoprobe Detects Therapy-Induced Senescence in Lung Cancer, Fibrosis
A new injectable albumin-based nanoprobe allows noninvasive, longitudinal monitoring of cellular senescence burden via urine testing.