GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
Adipose Blocks Stored at -80 °C Maintain Multipotent Cell Viability
A protocol using commercial freezers and rapid thawing preserves 88% of stromal vascular fraction cells for up to four months.
Hierarchical Retinal Circuits Enhance Low-Contrast Detection in Mice and Humans
A dual-mode synaptic architecture using glutamate clouds and driver cells improves signal sensitivity beyond independent cell channels.
CHK1 Inhibition Sensitizes Experimental Glioma to CDK4/6 Blockade
CRISPR screening identifies AMBRA1 and CCNE1 as drivers of resistance while suggesting dual CHK1 and CDK4/6 targeting as a viable strategy.
CEP41 Mutations Alter Cortical Neuron Ratios in Human Organoid Models
The R242H mutation shortens primary cilia and disrupts the balance of excitatory and inhibitory neurons during brain development.
Photon-Counting CT Shows Higher Spatial Resolution for Lung Nodules in Phantom Study
New data suggest photon-counting technology maintains noise stability and resolution better than energy-integrating systems at low doses.
Plasmodium knowlesi Adapts In Vitro to Infect Duffy-Negative Erythrocytes
A chimeric gene allows the zoonotic parasite to bypass the Duffy-antigen receptor, suggesting potential for wider geographic spread.
Robotic CT-Guided Cannula Placement Shows Sub-Millimeter Precision in Phantom Models
Researchers placed multiple convection-enhanced delivery cannulas in under 30 minutes with high stereotactic accuracy.
Low-Value Evaluation Increases Decision Thresholds and Neural Conflict in Choice Tasks
Shifting focus toward negative attributes slows evidence accumulation and increases attentional demand without altering final outcomes.
Shared Mitochondrial Pathways Identified Across 23 Neurodevelopmental Risk Genes
Researchers used CRISPR to map how diverse genetic mutations converge on common molecular targets, allowing for drug testing in animal models.
SF3B1 Mutations Increase DCAF16 Expression to Create Targeted Therapeutic Vulnerability
Splicing alterations in noncoding mRNA regions drive gain-of-function protein expression, allowing selective degradation of cancer targets.
CFLIP Inhibition Triggers Extrinsic Apoptosis in ABC Subtype Lymphoma Models
Murine and human cell studies identify cFLIP as a requirement for B-cell lymphomagenesis and a potential target in refractory disease.