Acquired Anosmia Affects Quality of Life More Than Congenital Anosmia
A study of 59 patients reveals how the origin and duration of anosmia influence perceived impairment and coping.
ICU Readmission Increases 60-Day Mortality Regardless of Frailty Status
A large registry study finds frail, readmitted patients face the highest mortality, but frailty does not alter readmission's incremental risk.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Spatial Proteomics Identifies Plaque-Associated Microglia in Alzheimer's Brains
A new imaging technology reveals a specific microglial subpopulation linked to dense amyloid-beta plaques in human Alzheimer's disease.
AD109 Reduces Apnea-Hypopnea Index in PAP-Intolerant OSA Patients
An oral combination of aroxybutynin and atomoxetine significantly improved objective respiratory metrics over 26 weeks.
Stag2 Deficiency Reprograms GATA1 Binding, Driving Dyserythropoiesis in Myelodysplastic Syndromes
Loss of Stag2 alters chromatin accessibility, redirecting GATA1's transcriptional activity from erythroid to megakaryocyte pathways.
Genetic Maps Reveal Psychiatric Disorder Clusters, Clinical Feature Links
A Swedish register study maps genetic risk for 12 disorders, showing how liabilities vary with sex, onset age, and recurrence.
MSC-Exos Restore Hippocampal Neuron Morphology After Stress via Wnt5a Pathway
Mesenchymal stem cell-derived exosomes mitigate stress-induced morphological deficits in hippocampal neurons through a specific signaling pathway.
PU.1 Activation Identifies Low-Risk MDS Patients at High Progression Risk
A molecular signature involving PU.1 genomic occupancy distinguishes a subset of low-risk MDS patients prone to progression and reduced survival.
Periventricular Lesions Drive Cognitive Decline by Disrupting Cholinergic Pathways in Parkinson's
White matter injury triggers cortical terminal loss and retrograde atrophy, identifying a structural biomarker for cognitive risk.
PET Imaging Tracks Metabolic Decline Across ALS Clinical Stages
A large cohort study links King's staging to progressive loss of brain connectivity and transient cerebellar recruitment in ALS.
Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.