The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
This week
24 stories-
Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults
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Nitrous Oxide Addiction Linked to DCN-VTA Circuit, AMPA Receptor Potentiation
A new study identifies how nitrous oxide directly enhances AMPA receptor function in the DCN-VTA circuit, mediating its rewarding effects.
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Nitrous Oxide Reward Driven by DCN-VTA Circuit, AMPA Receptor Potentiation
A new study in animal models identifies the specific neural circuit and molecular mechanism underlying nitrous oxide's rewarding effects.
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IDH1 Mutations in Prostate Cancer Link High Stage/Grade to Favorable Outcomes
A retrospective analysis identifies IDH1 mutations as a marker for improved survival in prostate cancer, despite aggressive initial presentation.
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CPES Score May Better Identify PE Patients Needing Advanced Intervention
A retrospective study suggests the Composite Pulmonary Embolism Shock score offers improved prediction for advanced interventions in PE.
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CPES Score Identifies PE Patients Needing Advanced Intervention
A retrospective study finds the Composite Pulmonary Embolism Shock score particularly effective in predicting the need for advanced therapies.
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Urinary Nanoprobe Detects Therapy-Induced Senescence in Lung Cancer, Fibrosis
A new injectable albumin-based nanoprobe allows noninvasive, longitudinal monitoring of cellular senescence burden via urine testing.
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GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
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PsA Improvement Thresholds Vary by Baseline Disease Activity, Not Prior TNFi Exposure
Minimal clinically important improvement (MCII) thresholds in psoriatic arthritis depend on baseline disease severity, guiding personalized treatment.
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Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.
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UK and Ireland Neonatal Stroke Incidence: 9.0 per 100,000 Live Births
A new surveillance study details the epidemiology, clinical patterns, and short-term outcomes of neonatal stroke in the UK and Ireland.
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UK Neonatal Stroke Incidence: 9.0 per 100,000 Live Births, Varied Presentations
A new surveillance study details the incidence, clinical features, and initial management of neonatal stroke in the UK and Ireland.
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Dual PH Therapy Before BPA Reduces Complications, Improves Outcomes in CTEPH
A Dutch registry study indicates that dual pulmonary hypertension-targeted medical therapy improves safety and efficacy of balloon pulmonary angioplas
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Dual PH-Targeted Therapy Reduces BPA Complications, Improves Outcomes in CTEPH
A Dutch registry study indicates that dual pulmonary hypertension-targeted medical pretreatment lowers periprocedural risks and enhances clinical bene
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Teriparatide Plus Zoledronic Acid Does Not Reduce Fracture Risk in Adults with OI
A randomized trial found that while combination therapy increased bone mineral density, it did not lower fracture incidence.
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Macaque V1 Neuron Activity Links Internal States to Reaction Time, Perceptual Choice
New research in macaque monkeys reveals how primary visual cortex neuron membrane potential dynamically influences visual task performance.
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Familial Brain Pattern Similarity Links to Psychotic Disorder Risk in Offspring
A new index quantifying cortical thickness similarity between parents with psychosis and their offspring correlates with psychiatric diagnoses.
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Acute Kidney Injury Predicts Increased Risk of Stroke and Dementia
A meta-analysis of 11 million patients links acute renal insults to a 35% higher stroke risk and nearly fivefold 90-day poststroke mortality.
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Circulating Tumor DNA Predicts Progression-Free Survival in Hodgkin Lymphoma
A validated sequencing assay identifies patients at high risk for relapse after two cycles of chemotherapy in the GHSG HD21 trial.
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Intracranial Recordings Map Immediate and Distal Neural Responses to Magnetic Stimulation
A review of human and primate data shows single-pulse TMS excites neurons in 2 milliseconds and modulates networks for up to 40 minutes.
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Digital Interventions Improve Eating Disorder Symptoms and Comorbid Mental Health
A meta-analysis of 36 trials shows digital tools offer consistent, durable benefits for core eating disorder symptoms and associated mental health con
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Maternal Genetic Variants Linked to Aneuploid Conception Identified in Review
A systematic review identifies specific maternal genetic variants associated with aneuploid conceptions, offering new insights for infertility diagnos
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CMR and NT-proBNP Improve Risk Prediction in Hypertrophic Cardiomyopathy
A prospective registry study identifies myocardial scar and natriuretic peptide levels as key predictors of long-term adverse outcomes.
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Memory Deficits Persist in Multiple Sclerosis Despite Preserved Processing Speed
Modern treatment eras show a shift where cognitive slowing is no longer the primary deficit in relapsing-remitting multiple sclerosis.