The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
This week
24 stories-
Cerebellar Disinhibitory Circuit Controls Motor Learning Signals
New research in mice reveals how synchronized climbing fiber activity selectively gates error signals to enable adaptive motor learning.
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Ensitrelvir Reduces COVID-19 Incidence by 6.1% in Household Contacts
An oral SARS-CoV-2 3C-like protease inhibitor significantly lowers infection rates when given as postexposure prophylaxis.
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Secreted GPNMB Drives Alpha-Synuclein Spread in Parkinson's Disease
A new study identifies a microglial-neuronal feedback loop involving GPNMB that exacerbates alpha-synuclein pathology, offering a therapeutic target.
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Daratumumab-VCd Improves Survival, Organ Function in AL Amyloidosis
Final ANDROMEDA analysis confirms sustained benefits of D-VCd for newly diagnosed light-chain amyloidosis, including overall survival.
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Skin Biopsy Distinguishes Body-First from Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein signatures and seeding activity identify divergent pathological origins and autonomic denervation patterns.
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TES Criteria Show Low Accuracy for CTE-NC Diagnosis
A study of 1,038 brain bank cases reveals that traumatic encephalopathy syndrome criteria poorly predict postmortem chronic traumatic encephalopathy.
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Critically Ill Women in India Receive Less Organ Support, Show Similar Mortality
A large registry-embedded cohort study reveals sex-based differences in critical care provision without impacting adjusted mortality.
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Indian ICUs: Women Receive Less Organ Support, Similar Mortality to Men
A large registry-embedded cohort study in India reveals sex-based differences in critical care resource utilization.
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Gram-Negative Bacteria Dominate Neonatal Infection Deaths in LMICs
A multicountry study identifies Klebsiella pneumoniae and Acinetobacter baumannii as leading causes of neonatal infection mortality.
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Intracranial Stimulation Prevents Attentional Lapses in Children
A new study identifies a real-time neural signature for attentional control, enabling targeted intervention to improve attention shifts.
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Recent Trauma Exposure Linked to Increased V1 Thickness, Independent of PTSD Symptoms
A two-sample study identifies greater V1 thickness in recently trauma-exposed individuals, a finding distinct from PTSD symptom severity.
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Tfr2 Essential for Acute Hepcidin Induction in Tfr1-Deficient Mouse Hepatocytes
A murine study reveals that transferrin receptor 2 and HFE must cooperate to trigger hepcidin during rapid iron fluctuations.
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Hippocampal Lesions Reduce Visual Working Memory Precision in Epilepsy Patients
Postoperative hippocampal damage selectively degrades memory quality rather than quantity, offering a marker for functional monitoring.
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Extra-Pulmonary TB Linked to Persistent Lung Function Deficits
A new study reveals that extra-pulmonary tuberculosis survivors experience lasting respiratory impairment, similar to pulmonary TB.
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Extrapulmonary TB Linked to Persistent Lung Function Deficits, Respiratory Symptoms
A new study reveals that individuals treated for extrapulmonary tuberculosis frequently develop lasting ventilatory defects and respiratory symptoms.
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Sutureless Robotic Partial Nephrectomy Noninferior to Renorrhaphy for Renal Tumors
A randomized controlled trial indicates sutureless off-clamp robotic partial nephrectomy offers comparable surgical quality for cT1-2N0M0 renal tumors
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Reduced ULK1 Links Impaired Cellular Clearance to Alzheimer's Pathology
Lower levels of ULK1 correlate with Alzheimer's disease, and its upregulation improves pathology and cognition in animal models.
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Thalamic Connections to Medial Prefrontal Cortex Predict Impulsivity
A new study links specific thalamic subregions, defined by cortical connectivity, to individual differences in delay discounting.
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Thalamic-MPFC Connectivity Linked to Individual Differences in Impulsivity
A new study identifies specific thalamic subregions connected to the medial prefrontal cortex as structural correlates of delay discounting.
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CCL19 Tracks IgG4-Related Disease Activity, Supplements IgG4 Levels
A new study identifies C-C motif chemokine ligand 19 as a dynamic serum biomarker for monitoring IgG4-RD treatment response and relapse.
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ECPR for OHCA in Singapore: Cost-Effective, but Sensitive to Transport Delays
A simulation-based analysis suggests ECPR for refractory OHCA in Singapore is cost-effective, though transport time significantly impacts its economic
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Telitacicept Reduces Proteinuria in IgA Nephropathy: Phase 3 Interim Analysis
A dual BAFF and APRIL antagonist significantly lowers urinary protein-to-creatinine ratio in adults with IgA nephropathy at high risk of progression.
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Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.
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Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults