Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma…
Randomized Controlled Trial
Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
Randomized Controlled Trial
Amoxicillin Equals Amoxicillin-Clavulanate for Acute Sinusitis
A nationwide cohort study shows standard amoxicillin is as effective as amoxicillin-clavulanate but avoids higher risks of C. difficile.
Randomized Controlled Trial
Serious Games Reduce Geriatric Trauma Undertriage in Nontrauma Centers
A randomized trial of 800 emergency physicians shows digital simulation training improves adherence to triage guidelines for older adults.
Non-Randomized Controlled Trial
Risk-Adapted Therapy Improves Survival in Pediatric Acute Myeloid Leukemia
Refined stratification using measurable residual disease and genetics increased 3-year overall survival to 83.9% in a large cohort.
Randomized Controlled Trial
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Randomized Controlled Trial
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.
Randomized Controlled Trial
Zongertinib Drives High Response in First-Line HER2-Mutant Lung Cancer
The selective HER2 inhibitor achieved a 76% objective response rate and durable progression-free survival in treatment-naive patients.
Randomized Controlled Trial
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
Randomized Controlled Trial
Fecal Transplant Fails to Decolonize Resistant Bacteria in GI Disease
A randomized trial shows single-dose fecal microbiota transplant does not reduce multidrug-resistant organisms or resistance genes.
Randomized Controlled Trial
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
Randomized Controlled Trial
Asundexian Reduces Recurrent Stroke Without Increasing Major Bleeding
Adding the Factor XIa inhibitor asundexian to standard antiplatelet therapy safely lowers recurrent stroke risk in high-risk patients.
Non-Randomized Controlled Trial
Early EEG Findings Guide Shorter Sedation After Cardiac Arrest
Patients with favorable EEG patterns within 12 hours of arrest saw mechanical ventilation and ICU stays reduced by over 50 percent.
Randomized Controlled Trial
Genicular Artery Embolization Shows No Benefit Over Sham for Knee Osteoarthritis
A randomized trial finds that 12-month pain reduction after genicular artery embolization is statistically equivalent to a sham procedure.
Randomized Controlled Trial
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Randomized Controlled Trial
Low-Calorie Feeding Does Not Worsen Kidney Function in Shock
A post hoc analysis of 3,036 patients shows early restrictive diets are safe for the kidneys, even with preexisting dysfunction.
Randomized Controlled Trial
Rapid Susceptibility Testing Speeds Antibiotic Adjustments but Not Outcomes
While rapid testing accelerated antibiotic adjustments by 14 hours, it did not improve 30-day survival or reduce deleterious events.
Randomized Controlled Trial
Lifestyle Intervention Benefits Cognition in Older Adults With Low Hippocampal Volume
A randomized trial shows intensive lifestyle coaching preserves cognition in high-risk patients despite unchanged brain biomarker trajectories.
Randomized Controlled Trial
Oral Celecoxib and Ciprofloxacin Slow Functional Decline in ALS
A phase 2b trial shows the fixed-dose combination is safe and reduces the risk of severe complications over 18 months in early-stage ALS.
Randomized Controlled Trial
Apps for Alcohol Use Do Not Improve Mood Beyond Standard Care
In a randomized trial, digital tools added to standard care did not further reduce depression or anxiety in adults with alcohol dependence.
Non-Randomized Controlled Trial
Structured Exercise Improves Sleep and Executive Function in Preteens With Autism
A 10-to-12-week physical activity program objectively reduced sleep fragmentation and improved problem-solving in children with autism.
Randomized Controlled Trial
Tumor Debulking Adds Toxicity Without Survival Benefit in Metastatic Colorectal Cancer
Adding tumor debulking to chemotherapy fails to extend survival and increases severe adverse events in metastatic colorectal cancer.
Randomized Controlled Trial
12-Week Diet and Exercise Program Improves Post-ICU Physical Function
A 12-week regimen of exercise and protein supplementation significantly improves physical functioning in long-stay ICU survivors.
Randomized Controlled Trial
Limiting ICU Wrist Restraints Fails to Increase Delirium-Free Days
A restrictive wrist-strap protocol in mechanically ventilated adults did not improve delirium-free days or increase self-extubation risk.
Randomized Controlled Trial
High-Flow Oxygen Lowers Intubation but Does Not Improve Survival
High-flow nasal cannula therapy reduces intubation rates in acute hypoxemic respiratory failure without altering 28-day mortality.
Randomized Controlled Trial
Prehospital Whole Blood Shows No Survival Benefit Over Component Therapy
A randomized trial of 616 trauma patients found prehospital whole blood did not reduce 24-hour mortality or massive transfusion needs.
Randomized Controlled Trial
Web-Based School Program Reduces New-Onset Mental Health Problems
An eight-session internet intervention focused on stress management lowered the one-year incidence of mental health issues from 28% to 21%.
Randomized Controlled Trial
Community Care for HIV, HTN, Diabetes Matches Clinic-Based Model
A trial in Tanzania and Uganda found non-inferior HIV suppression and comparable cardiometabolic control in a community-based model.
Randomized Controlled Trial
Women Face Worse Functional Recovery After Intensive Care EEG
Despite similar acute management and mortality, critically ill women are half as likely as men to achieve favorable long-term recovery.
Randomized Controlled Trial
Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
Randomized Controlled Trial
Obinutuzumab Shows High Efficacy in Active Systemic Lupus Erythematosus
A phase 3 trial shows the anti-CD20 antibody obinutuzumab significantly improves clinical responses and reduces flares in active lupus.