Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma…
Randomized Controlled Trial
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Non-Randomized Controlled Trial
Vuzix Head-Mounted Device Scores Highest in Prehospital Stroke Triage Simulation
A comparative study finds neurologists prefer head-mounted video quality while paramedics favor smartphone usability for remote triage.
Randomized Controlled Trial
Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
Randomized Controlled Trial
Focal Coronary Disease Predicts Greater Angina Relief After Stenting
New ORBITA-2 data show focal lesions derive significantly more placebo-controlled benefit from PCI than diffuse disease patterns.
Randomized Controlled Trial
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Randomized Controlled Trial
Nirmatrelvir-Ritonavir Fails to Reduce Hospitalization in Vaccinated Outpatients
Two randomized trials show no significant clinical benefit for high-risk adults with prior immunity from vaccination or infection.
Randomized Controlled Trial
Early Enteral Nutrition Reduces Complication Burden After Pancreatoduodenectomy
A randomized trial shows immediate tube feeding lowers the comprehensive complication index in patients at high nutritional risk.
Randomized Controlled Trial
Funnel-Shaped Mesh Reduces Parastomal Hernia Risk After Rectal Cancer Surgery
A randomized trial shows prophylactic mesh lowers three-year clinical hernia rates from 39% to 10% without increasing complications.
Non-Randomized Controlled Trial
Telepractice PTR-F Improves Parent Fidelity in Chinese American Families
A culturally adapted behavioral intervention delivered remotely increased parent adherence and reduced challenging behaviors in autistic children.
Randomized Controlled Trial
Tucidinostat Improves Event-Free Survival in Double-Expressor B-Cell Lymphoma
Adding a histone deacetylase inhibitor to R-CHOP increases complete response rates and reduces progression risk in high-risk patients.
Randomized Controlled Trial
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Randomized Controlled Trial
Tranexamic Acid Reduces Major Bleeding in Urologic Surgery
A randomized trial of 1,124 patients shows TXA reduces major bleeding by 3.4% without significantly increasing 30-day thrombotic risk.
Randomized Controlled Trial
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Randomized Controlled Trial
Estradiol Patches Noninferior to LHRH Agonists in Prostate Cancer
A phase 3 trial shows transdermal estradiol maintains metastasis-free survival while reducing hot flashes in locally advanced disease.
Randomized Controlled Trial
Participation-Focused Training Improves Immediate Post-Stroke Executive Function in Randomized Trial
Strategy training shows short-term cognitive gains in stroke survivors, though benefits do not persist at three-month follow-up.
Non-Randomized Controlled Trial
Immune-Guided Strategy Reduces CMV Disease in Kidney Transplant Recipients
Early assessment of cell-mediated immunity allows for targeted prophylaxis, lowering symptomatic disease rates in seropositive patients.
Randomized Controlled Trial
Improved House Design Reduces Malaria and Respiratory Infections in Children
A cluster-randomized trial in rural Africa shows that Star Homes lower malaria incidence by 44% and improve linear growth in children.
Randomized Controlled Trial
Immersive Virtual Reality Improves Naming in Chronic Non-Fluent Aphasia
A randomized trial shows immersive therapy yields higher gains in oral motor function and patient enjoyment than conventional methods.
Randomized Controlled Trial
Memantine Reduces Premature Atrial Contractions and New-Onset Atrial Fibrillation
A phase 2 trial shows targeting cardiac N-methyl-D-aspartate receptors significantly lowers atrial ectopy and tachyarrhythmia burden.
Randomized Controlled Trial
Adding Tobramycin to Vancomycin Powder Does Not Reduce Tibial Fracture Infections
A randomized trial of 1528 patients shows dual intrawound antibiotic powder offers no benefit over vancomycin alone in high-risk fractures.
Randomized Controlled Trial
Eccentric Cycling Matches Concentric Training for Post-COVID-19 Walking Recovery
An 8-week trial shows eccentric cycling is safe and improves walking distance, though it offers no advantage over concentric exercise.
Non-Randomized Controlled Trial
Mosunetuzumab and Polatuzumab Vedotin Show High Response in Refractory MCL
A phase 2 trial reports a 78.6% complete response rate in patients with mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure.
Randomized Controlled Trial
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Randomized Controlled Trial
Seven-Day Low-Plastic Intervention Lowers Urinary Phthalates and Bisphenol A
A randomized trial shows that minimizing plastic contact in food and personal care reduces endocrine disruptors linked to metabolic risk.
Randomized Controlled Trial
Thrombectomy Increases Tissue Salvage in Distal Vessel Occlusion Stroke
A post hoc analysis of the DISTAL trial shows endovascular therapy preserves more at-risk brain tissue than medical management alone.
Non-Randomized Controlled Trial
Cibisatamab and FAP-4-1BBL Show Activity in Refractory Colorectal Cancer
A phase 1b trial finds that combining a CEA-targeted bispecific antibody with localized 4-1BB co-stimulation induces objective responses.
Randomized Controlled Trial
Telehealth Integration Does Not Prevent Quality of Life Decline in Palliative Care
A randomized trial of 182 patients found no significant differences in symptom burden or security between telehealth and standard care.
Non-Randomized Controlled Trial
Large Language Models Reduce Radiology Reporting Time and Transcription Errors
A multicenter study finds LLMs faster than conventional speech recognition but notes inconsistent efficiency and new error types.
Non-Randomized Controlled Trial
Cilta-cel Induces Universal MRD Negativity in High-Risk Smoldering Multiple Myeloma
A phase 2 trial shows 100% of patients achieved deep, sustained responses without prior induction therapy or disease progression.
Randomized Controlled Trial
Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.