Specific RehaCom Modules Predict Processing Speed Gains in Progressive Multiple Sclerosis
Progression in attention-based modules and baseline characteristics like IQ and age determine cognitive outcomes in progressive MS.
NIRS-Guided Resuscitation Improves Early Motor Scores in Preterm Infants
A COSGOD III sub-study shows that monitoring cerebral oxygenation in the first 15 minutes of life correlates with better motor repertoire.
Targeted Agents Fail to Extend Survival in Pediatric Brainstem Glioma
The BIOMEDE trial finds no survival benefit for erlotinib, dasatinib, or everolimus, but identifies TP53 as a key prognostic marker.
Balanced Fluids and Saline Show Similar Outcomes in Pediatric Septic Shock
A large trial of over 8,000 children found no difference in kidney events or mortality between balanced crystalloids and 0.9% saline.
Triple-Pill Therapy Reduces Recurrent Stroke Risk After Intracerebral Hemorrhage
A low-dose combination of telmisartan, amlodipine, and indapamide lowered systolic blood pressure and major cardiovascular events.
Brolucizumab Preserves Vision Better Than Laser in Diabetic Retinopathy
The Phase 3 CONDOR trial shows brolucizumab 6 mg maintains visual acuity and regresses disease more effectively than panretinal laser.
Left Bundle Branch Pacing Reduces Cardiomyopathy Risk in High-Burden Patients
A randomized trial shows left bundle branch pacing lowers composite clinical events and improves ventricular function over 36 months.
Baricitinib Noninferior to Etanercept for Reducing Ultrasound-Assessed Synovitis
A phase IV trial shows baricitinib, with or without methotrexate, matches etanercept in objective measures of joint inflammation.
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Focal Coronary Disease Predicts Greater Angina Relief After Stenting
New ORBITA-2 data show focal lesions derive significantly more placebo-controlled benefit from PCI than diffuse disease patterns.