Nirmatrelvir-Ritonavir Fails to Reduce Hospitalization in Vaccinated Outpatients
Two randomized trials show no significant clinical benefit for high-risk adults with prior immunity from vaccination or infection.
Early Enteral Nutrition Reduces Complication Burden After Pancreatoduodenectomy
A randomized trial shows immediate tube feeding lowers the comprehensive complication index in patients at high nutritional risk.
Funnel-Shaped Mesh Reduces Parastomal Hernia Risk After Rectal Cancer Surgery
A randomized trial shows prophylactic mesh lowers three-year clinical hernia rates from 39% to 10% without increasing complications.
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Tucidinostat Improves Event-Free Survival in Double-Expressor B-Cell Lymphoma
Adding a histone deacetylase inhibitor to R-CHOP increases complete response rates and reduces progression risk in high-risk patients.
Tranexamic Acid Reduces Major Bleeding in Urologic Surgery
A randomized trial of 1,124 patients shows TXA reduces major bleeding by 3.4% without significantly increasing 30-day thrombotic risk.
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Estradiol Patches Noninferior to LHRH Agonists in Prostate Cancer
A phase 3 trial shows transdermal estradiol maintains metastasis-free survival while reducing hot flashes in locally advanced disease.
Participation-Focused Training Improves Immediate Post-Stroke Executive Function in Randomized Trial
Strategy training shows short-term cognitive gains in stroke survivors, though benefits do not persist at three-month follow-up.
Improved House Design Reduces Malaria and Respiratory Infections in Children
A cluster-randomized trial in rural Africa shows that Star Homes lower malaria incidence by 44% and improve linear growth in children.
Immersive Virtual Reality Improves Naming in Chronic Non-Fluent Aphasia
A randomized trial shows immersive therapy yields higher gains in oral motor function and patient enjoyment than conventional methods.
Memantine Reduces Premature Atrial Contractions and New-Onset Atrial Fibrillation
A phase 2 trial shows targeting cardiac N-methyl-D-aspartate receptors significantly lowers atrial ectopy and tachyarrhythmia burden.