Adding Tobramycin to Vancomycin Powder Does Not Reduce Tibial Fracture Infections
A randomized trial of 1528 patients shows dual intrawound antibiotic powder offers no benefit over vancomycin alone in high-risk fractures.
Eccentric Cycling Matches Concentric Training for Post-COVID-19 Walking Recovery
An 8-week trial shows eccentric cycling is safe and improves walking distance, though it offers no advantage over concentric exercise.
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Seven-Day Low-Plastic Intervention Lowers Urinary Phthalates and Bisphenol A
A randomized trial shows that minimizing plastic contact in food and personal care reduces endocrine disruptors linked to metabolic risk.
Thrombectomy Increases Tissue Salvage in Distal Vessel Occlusion Stroke
A post hoc analysis of the DISTAL trial shows endovascular therapy preserves more at-risk brain tissue than medical management alone.
Telehealth Integration Does Not Prevent Quality of Life Decline in Palliative Care
A randomized trial of 182 patients found no significant differences in symptom burden or security between telehealth and standard care.
Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
Amoxicillin Equals Amoxicillin-Clavulanate for Acute Sinusitis
A nationwide cohort study shows standard amoxicillin is as effective as amoxicillin-clavulanate but avoids higher risks of C. difficile.
Serious Games Reduce Geriatric Trauma Undertriage in Nontrauma Centers
A randomized trial of 800 emergency physicians shows digital simulation training improves adherence to triage guidelines for older adults.
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.