Awake Mapping for Grade 2 Glioma Reduces Intractable Epilepsy Burden
Extensive resection of IDH-mutant tumors improves seizure freedom and return-to-work rates, particularly for insular lesions.
Intracranial Recording Maps Immediate and Sustained Effects of Brain Stimulation
Direct neural recordings in humans and primates reveal that magnetic pulses trigger cellular excitation in 2 milliseconds.
Autologous Mesenchymal Cells Reduce Neuroinflammation in Chronic Brain Injury
A Phase 1/2a trial shows intravenous stromal cells improve white matter integrity and reduce immune cell density in the chronic TBI brain.
Stop-Short Technique Doubles Carotid Dissection Risk During TCAR
A registry analysis of 25,346 patients identifies procedural and demographic factors linked to intraoperative arterial injury.
CHK1 Inhibition Sensitizes Experimental Glioma to CDK4/6 Blockade
CRISPR screening identifies AMBRA1 and CCNE1 as drivers of resistance while suggesting dual CHK1 and CDK4/6 targeting as a viable strategy.
Iatrogenic Amyloid Angiopathy Shows Higher Amyloid Burden Than Sporadic Cases
Patients with iatrogenic disease exhibit distinct biomarker profiles and lower APOE ε4 frequency compared to those with sporadic disease.
Deep Learning Automates PET RANO Criteria Extraction in Glioma Imaging
An externally validated model achieves high agreement with experts in quantifying metabolic tumor volume and tumor-to-background ratios.
Fetal MRI Scoring System Quantifies Severity in Trisomy 13, 18, and CHARGE
A new morphological score and network analysis map phenotypic heterogeneity to assist in prenatal counseling and management planning.
Post-Thrombectomy Blood Pressure Drops Linked to Increased Disability
Systolic decreases of 40 mm Hg or more within 24 hours of successful recanalization correlate with worse functional recovery.
Middle Meningeal Artery Embolization Reduces Subdural Hematoma Recurrence
Adjunctive embolization after surgery lowered symptomatic recurrence from 28% to 4.3% in a randomized trial of 186 patients.
Normative Modeling Maps Individual Brain Deviations in Traumatic Brain Injury
Patient-specific MRI analysis reveals unique structural changes that traditional group-level averages often obscure in moderate-to-severe TBI.
Cesium-131 Collagen Tiles Improve Local Control in Recurrent Meningioma
A phase 2 trial shows resection plus brachytherapy achieves 48% local control at five years for aggressive, recurrent meningiomas.