Subthalamic Signal Propagation Predicts Parkinsonian Motor State
Movement-related high-frequency oscillations propagate along the inferior-superior axis, correlating with levodopa response.
Neurosurgeons Disagree on Resectability in Recurrent Glioblastoma Trial
A post-hoc analysis reveals low inter-rater agreement on surgical feasibility and no link between surgeon consensus and survival.
Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
Early Radiographic Response Poorly Predicts Local Control in Brain Metastases
A large cohort study finds that stable disease and partial response carry similar recurrence risks after radiation therapy.
Gamma Knife Surgery Provides Durable Control of Vestibular Schwannoma
A 30-year study shows true tumor progression is rare after 10 years, supporting reduced imaging for patients stable at the 5-year mark.
BRAF V600E Mutation Predicts Early Recurrence in Rathke Cleft Cysts
A retrospective analysis of 383 sellar lesions suggests BRAF-positive cysts behave like papillary craniopharyngiomas and require reclassification.
Penetrating Brain Injury Mortality Reaches 42% While Prophylaxis Compliance Lags
Despite high mortality, 70% of survivors achieve favorable outcomes, though adherence to antibiotic and seizure protocols remains low.
Prefrontal Cortex Origin for Rhythmic Ictal Nonclonic Hand Motions
Intracerebral recordings show that specific hand motions often linked to temporal lobe epilepsy can originate in the middle frontal gyrus.
Transcortical Mapping for Insular Glioma Limits Deficits and Improves Survival
A 500-case analysis identifies specific residual volume thresholds that correlate with survival while keeping permanent deficits under 4%.
Interneuron Loss Fails to Amplify mTOR-Related Seizures in Mice
A two-hit model shows that hippocampal interneuron depletion triggers transient seizures but does not synergize with Pten mutations.
Preexisting Mental Disorders Increase Mortality After Spinal Injury
A cohort study finds younger patients with dual diagnoses face a 17-fold higher mortality risk following traumatic spinal injury.
Rapid Inter-Temporal Seizure Spread Linked to Poor Surgical Outcomes
Deep learning analysis of 275 seizures shows that extensive cortical involvement and rapid propagation correlate with surgical failure.