Blood-Brain Barrier Integrity Dictates Serum GFAP Accuracy in Cognitive Impairment
A study of 74 patients shows that serum biomarkers only strongly correlate with central pathology when the blood-brain barrier is disrupted.
Exogenous Hormones Associate With Reduced Dementia Risk in UK Biobank Cohort
Use of oral contraceptives and hormone replacement therapy correlates with lower rates of Alzheimer's disease and vascular dementia.
Clinical Criteria for LATE Distinguish Cognitive Trajectories from Alzheimer Disease
A study of 3,606 patients shows isolated LATE progresses slower than Alzheimer disease, while comorbid pathology accelerates decline.
Corticostriatal Connectivity Shifts as Putaminal Dopamine Depletion Reaches 50 Percent
A study of 326 patients identifies a critical threshold where compensatory motor circuits fail and clinical symptoms accelerate.
Apixaban Reduces Recurrent Stroke in Patients Without High-Risk Hypertension
An ARCADIA trial analysis shows apixaban is more effective than aspirin only when severe hypertension and cardiac hypertrophy are absent.
EEG Topological Mapping Distinguishes Mild from Moderate Stroke with 86% Accuracy
Persistent homology identifies higher-order network disruptions in the prefrontal cortex to improve objective stroke severity assessment.
Lower Tau PET Sensitivity in Older Men Reflects Reduced Tangle Density
Flortaucipir PET sensitivity for advanced Alzheimer pathology drops to 42% in patients over 83, mirroring lower biological tangle burdens.
Sex Not Independently Linked to Post-Arrest Neurological Recovery
Observed survival disparities between men and women disappear after adjusting for initial rhythm and arrest etiology.
7 Tesla MRI Reveals Rapid Neural Connectivity Shifts During Cognitive Tasks
Healthy adults transition from surveillance to automated processing within minutes of mental exertion despite stable behavioral performance.
AI Model Predicts Glioblastoma Infiltration Beyond Visible Tumor Margins
A prospective trial validates an AI tool using biopsies to map microscopic tumor spread and predict survival in glioblastoma patients.
Bitemporal ECT and rTMS Plus SSRIs Reduce Suicidal Ideation
A network meta-analysis of 58 trials finds nonconvulsive brain stimulation alone is ineffective for suicidal ideation without medication.
Advanced MRI Detects Occult Neuronal Loss in Asymptomatic MCA Occlusion
Soma and neurite density imaging reveals microstructural gray matter damage in stroke-free patients with chronic arterial occlusion.