Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
Ubiquinol Slows Motor Decline in Multiple System Atrophy Trial
A Phase 2 trial provides the first placebo-controlled evidence of disease modification by targeting mitochondrial dysfunction in MSA.
Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
Valproate Linked to Higher Mortality in Patients With Dementia and Epilepsy
A Swedish registry study finds lamotrigine and levetiracetam associated with better survival than valproate or carbamazepine.
Alteplase Before Thrombectomy Loses Value After 170 Minutes
A 16-country analysis shows bridging therapy for large vessel occlusion is only cost-effective when initiated early after stroke onset.
Plasma p-tau217 Assays Show High Specificity for Alzheimer’s Diagnosis
Three diverse assay technologies demonstrate 100% specificity in differentiating Alzheimer’s from vascular and frontotemporal dementias.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
Early EEG Findings Guide Shorter Sedation After Cardiac Arrest
Patients with favorable EEG patterns within 12 hours of arrest saw mechanical ventilation and ICU stays reduced by over 50 percent.
Asundexian Reduces Recurrent Stroke Without Increasing Major Bleeding
Adding the Factor XIa inhibitor asundexian to standard antiplatelet therapy safely lowers recurrent stroke risk in high-risk patients.
Glial GLRX3 Enzyme Drives Chronic Oxaliplatin-Induced Pain in Aged Models
A redox circuit in the dorsal root ganglion identifies potential biomarkers and therapeutic targets for age-related chemotherapy toxicity.
Neural Rhythms in Language and Default-Mode Networks Predict Reading Recall
Combined EEG and MRI data reveal that specific frequency patterns in brain networks correlate with a patient's ability to remember text.