Eleven-Protein Plasma Panel Identifies Parkinson’s Disease Across Four Cohorts
A machine learning model using 11 plasma proteins differentiated Parkinson’s from other neurological conditions with high accuracy.
Hypothalamic Astrocytes Drive Dexmedetomidine Sedation via Calcium Signaling in Mice
Researchers identified a specific astrocytic pathway that modulates inhibitory GABA currents to facilitate pharmacological sedation.
Bedside AI Analyzes EEG to Predict Cardiac Arrest Outcomes
A deep learning tool integrated into ICU monitors provides continuous prognostic trajectories for comatose patients within 36 hours.
Pediatric HIV Linked to Reduced Auditory Cortex Activation Despite Normal Hearing
Functional MRI reveals central auditory processing deficits in children with HIV that may bypass standard clinical audiometry.
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Acute Neurological Symptoms Predict Mortality in Heat-Related Illness
A Japanese study of 2,961 patients finds that impaired consciousness and seizures increase the risk of in-hospital death sevenfold.
White Matter Coupling Imbalance Marks Early HIV Neurocognitive Impairment
Structural demyelination and functional reorganization in white matter tracts correlate with clinical status in asymptomatic HIV patients.
Mediterranean Diet Preserves White Matter Integrity in Hispanic and Latino Adults
Higher adherence correlates with lower white matter hyperintensity volume and better global cognition through cardiovascular health pathways.
Venlafaxine Linked to Probable Induction of De Novo Vocal Tics
A case report identifies the first instance of vocal tics following SNRI use, likely due to fronto-striatal dopamine dysregulation.
Severe Childhood Malaria Impairs Cognition Up to 15 Years Later
Ugandan children who survive cerebral malaria or severe malarial anemia show persistent cognitive and math deficits up to 15 years later.
Thrombectomy Increases Tissue Salvage in Distal Vessel Occlusion Stroke
A post hoc analysis of the DISTAL trial shows endovascular therapy preserves more at-risk brain tissue than medical management alone.
Neuropsychiatric Symptoms and CSF Markers Predict General Paresis Outcomes
A 12-month study identifies depression, apathy, and baseline inflammatory markers as key indicators of prognosis in neurosyphilis.