Gaucher Disease Type 1 Carries 12% Parkinson Risk by Age 80
A registry study of 1,618 patients finds over 20% develop parkinsonian symptoms or dementia with Lewy bodies by the eighth decade.
Lower Rugby Tackle Height Reduces Ball-Carrier Risk but May Increase Tackler Impacts
A simulation of 23,081 tackles suggests that mandating lower hits redistributes neurotrauma risk between players rather than eliminating it.
Late-Onset MS Patients Receive Fewer High-Efficacy Therapies Despite Similar Disease Severity
A French registry study of 36,148 patients shows those diagnosed after age 50 are less likely to initiate or escalate treatment.
Glutamate Receptor Gene Variants Linked to Comorbid ADHD and Autism
Large-scale genomic analysis identifies specific structural variants in glutamatergic networks that distinguish complex ADHD phenotypes.
Xq28 Duplication Involving MECP2 Drives Multisystemic X-Linked Disability
A familial case report identifies a six-gene duplication at Xq28 causing severe neurological and cutaneous symptoms in males.
Low Cerebral Perfusion Pressure Increases Delirium Risk After Cardiac Surgery
A cohort study of 1,759 patients suggests that maintaining the balance between arterial and venous pressures may prevent delirium.
Clinical Milestones Predict Survival in Multiple System Atrophy
A study of 555 patients identifies late-stage markers and time-dependent prognostic factors to guide clinical management.
CHK1 Inhibition Sensitizes Experimental Glioma to CDK4/6 Blockade
CRISPR screening identifies AMBRA1 and CCNE1 as drivers of resistance while suggesting dual CHK1 and CDK4/6 targeting as a viable strategy.
Iatrogenic Amyloid Angiopathy Shows Higher Amyloid Burden Than Sporadic Cases
Patients with iatrogenic disease exhibit distinct biomarker profiles and lower APOE ε4 frequency compared to those with sporadic disease.
Six-Item Symptom Tool and Vestibular Screen Improve Concussion Diagnosis Accuracy
A streamlined 6-item index combined with a brief vestibular-ocular screen shows higher specificity than the standard 22-item checklist.
Multimorbidity Linked to Alzheimer's Biomarkers in Dementia-Free Adults
Cumulative chronic disease burden correlates with amyloid deposition, neurodegeneration, and vascular injury before cognitive symptoms emerge.
Pre-Diagnostic Beta-Carotene Levels Linked to Lower ALS Risk in Women
A nested case-control study finds sex-specific associations between plasma antioxidant profiles and future amyotrophic lateral sclerosis.