Awake Mapping for Grade 2 Glioma Reduces Intractable Epilepsy Burden
Extensive resection of IDH-mutant tumors improves seizure freedom and return-to-work rates, particularly for insular lesions.
Freezing of Gait Linked to Maladaptive Task Prioritization in Parkinson’s
Patients with freezing of gait maintain walking speed by sacrificing manual task accuracy, driven by impaired theta-band neural activity.
Apathy Mechanisms Differ Between Alzheimer's and Parkinson's Disease
Computational modeling reveals distinct effort-sensitivity profiles and neural signatures for motivational loss across neurodegenerative types.
SPAST Variant Mapping Predicts Disease Trajectory in Spastic Paraplegia Type 4
Genetic essentiality mapping and neurofilament levels differentiate rapid functional decline from moderate biphasic progression in SPG4.
Medial Temporal Lesions Impair Memory Precision Rather Than Capacity
Post-surgical data from 40 epilepsy patients show hippocampal damage increases recall variability without reducing the total items retained.
Identical EEG Bursts Signal Severe Loss of Brain Network Complexity
A multi-model study identifies identical burst suppression as a default state of simplified excitatory networks in irreversible coma.
Inflammatory Metabolite Index Predicts Ischemic Stroke Risk in Women
A signature of 102 metabolites, primarily lysophosphatidylcholines, identifies elevated stroke risk independently of traditional factors.
Cerebral Amyloid Angiopathy Increases Dementia Risk in Memory Clinics
A five-year study of 2,136 patients shows that radiologic markers of amyloid angiopathy predict progression from mild symptoms to dementia.
Intracranial Recording Maps Immediate and Sustained Effects of Brain Stimulation
Direct neural recordings in humans and primates reveal that magnetic pulses trigger cellular excitation in 2 milliseconds.
Autologous Mesenchymal Cells Reduce Neuroinflammation in Chronic Brain Injury
A Phase 1/2a trial shows intravenous stromal cells improve white matter integrity and reduce immune cell density in the chronic TBI brain.
Low Geriatric Nutritional Risk Index Increases Postoperative Delirium Risk
A meta-analysis of 12,332 patients finds that low preoperative nutritional scores correlate with a 62% higher risk of delirium.
Memory Deficits Precede Processing Speed Decline in Modern Multiple Sclerosis Care
A large cohort study suggests the traditional speed-centric model of cognitive impairment no longer applies to most current patients.