Brain Connectivity Subtypes Predict rTMS Response for Anhedonia in Depression
Patients with specific frontoparietal hyperconnectivity show significant improvement in anhedonia following neurostimulation.
Child Maltreatment Linked to Systemic Homeostatic Dysregulation
Recent trauma in children may disrupt physiological stability and delay development in males rather than accelerating biological aging.
Cell-Specific Gene Expression Analysis Identifies Schizophrenia Risk Drivers
Researchers mapped 466 causal genes across eight brain cell types, pinpointing MAU2 and PPP1R13B as high-priority therapeutic targets.
CEP41 Mutations Alter Cortical Neuron Ratios in Human Organoid Models
The R242H mutation shortens primary cilia and disrupts the balance of excitatory and inhibitory neurons during brain development.
Delaying Substance Use Until Age 21 Linked to 83% Lower Polysubstance Risk
A national survey of 92,233 adults shows that early initiation before age 18 significantly increases the risk of multiple concurrent addictions.
MRI Index Quantifies Alzheimer’s Pattern to Predict Dementia Onset
A structural brain vulnerability index identifies early neurodegeneration and predicts conversion from mild cognitive impairment.
Gut Microbiome Linked to Macrocephaly in NF1 Mouse Model
Sex-specific microbial signatures correlate with brain size and autism-like behaviors in mice with Neurofibromatosis type 1 mutations.
Astrocytic Hemichannel Overactivity Drives Prefrontal Circuit Deficits in Schizophrenia Models
Elevated connexin 43 in the prefrontal cortex triggers excessive glutamate release, offering a potential non-neuronal therapeutic target.
Blood MicroRNA Signatures Correlate With Hippocampal Volume and Atrophy Rates
Specific microRNA expression patterns in whole blood may serve as early markers for structural brain changes and neurodegenerative risk.
ME/CFS Linked to Reduced Bioactive Cortisol and Heightened Feedback Sensitivity
A meta-analysis of 46 studies confirms a neuroendocrine signature of low cortisol and HPA-axis hyporeactivity in chronic fatigue patients.
IL-15 Receptor Deficiency Drives Depressive Behaviors via Microglial Synapse Pruning in Mice
Loss of IL-15RA signaling triggers prefrontal cortex synapse loss through the CX3CL1 pathway, offering a potential target for depression.
Cell-Specific Genetic Mapping Links Neuronal and Immune Pathways to Neuropsychiatric Risk
Analysis of six major disorders identifies 345 risk genes, highlighting the role of microglia and astrocytes in disease pathogenesis.