Fecal Transplant Fails to Decolonize Resistant Bacteria in GI Disease
A randomized trial shows single-dose fecal microbiota transplant does not reduce multidrug-resistant organisms or resistance genes.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
TTVR Eliminates Severe Tricuspid Regurgitation in Real-World Registry
A US registry study of 1,034 patients shows 98% procedural success and significant functional gains with low 30-day mortality.
MTOR Hyperactivation Suppresses Autophagy and Drives Neuroinflammation in Schizophrenia
Restoring cellular waste clearance via mTOR inhibition reduces pro-inflammatory cytokines and glial activation in schizophrenia models.
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
Cajanine Reduces Anxiety and Fear Extinction Deficits in Female Mice
The compound modulates the ERβ/NF-κB pathway to alleviate neuroinflammation and behavioral symptoms in a sex-specific manner.
Early EEG Findings Guide Shorter Sedation After Cardiac Arrest
Patients with favorable EEG patterns within 12 hours of arrest saw mechanical ventilation and ICU stays reduced by over 50 percent.
Mechanism-Based Care Relieves Peripheral Edema in Advanced Cancer
A scoping review of 2,223 patients suggests targeted interventions like stenting and fluid management improve short-term symptom burden.
Asundexian Reduces Recurrent Stroke Without Increasing Major Bleeding
Adding the Factor XIa inhibitor asundexian to standard antiplatelet therapy safely lowers recurrent stroke risk in high-risk patients.
Silent Urate Deposits Found in 39% of Asymptomatic Hyperuricemia Patients
Standardized ultrasound reveals subclinical crystal deposition is linked to early joint erosion and synovial inflammation before the first gout flare.
Elobixibat Improves Chronic Constipation in Patients With Schizophrenia or Depression
Postmarketing surveillance shows increased defecation frequency and improved stool consistency with no serious adverse drug reactions.
Genicular Artery Embolization Shows No Benefit Over Sham for Knee Osteoarthritis
A randomized trial finds that 12-month pain reduction after genicular artery embolization is statistically equivalent to a sham procedure.