Alteplase Before Thrombectomy Loses Value After 170 Minutes
A 16-country analysis shows bridging therapy for large vessel occlusion is only cost-effective when initiated early after stroke onset.
Ambulance Lights and Sirens Save Only Three Minutes During Patient Transport
A study of 25,902 incidents suggests the modest time savings of emergent transport may not justify the tripled risk of collisions.
Risk-Adapted Therapy Improves Survival in Pediatric Acute Myeloid Leukemia
Refined stratification using measurable residual disease and genetics increased 3-year overall survival to 83.9% in a large cohort.
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.
Zongertinib Drives High Response in First-Line HER2-Mutant Lung Cancer
The selective HER2 inhibitor achieved a 76% objective response rate and durable progression-free survival in treatment-naive patients.
Plasma p-tau217 Assays Show High Specificity for Alzheimer’s Diagnosis
Three diverse assay technologies demonstrate 100% specificity in differentiating Alzheimer’s from vascular and frontotemporal dementias.
Obesity and Prediabetes Rates Rise Among Northern Great Plains Children
A multi-year screening of American Indian students shows obesity rates exceeding 40% and a doubling of prediabetes prevalence.
Macrophage PRMT9 Limits Myocardial Infarction Damage in Mice
Researchers found that PRMT9 triggers STAT1 degradation to suppress inflammation and reduce infarct size in experimental models.
AI Ensemble Matches Expert Consensus for Ultrasound Pneumothorax Detection
An explainable AI model achieved 100% sensitivity and specificity, reducing false positives compared to clinicians in M-mode imaging.
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
ILCOR Standardizes Reporting for Resuscitation Education Research
A new Utstein style consensus report defines 111 specific metrics to unify how training efficacy is measured across clinical cohorts.