Glial GLRX3 Enzyme Drives Chronic Oxaliplatin-Induced Pain in Aged Models
A redox circuit in the dorsal root ganglion identifies potential biomarkers and therapeutic targets for age-related chemotherapy toxicity.
Bariatric Surgery Reduces Lifetime Cardiovascular Risk More Than GLP-1 Agonists
A retrospective cohort study shows surgery achieves superior lifetime risk reduction and weight loss despite similar 10-year risk changes.
Sepsis-Associated Respiratory Mortality Rises Over 25 Years
A longitudinal analysis of 2 million deaths reveals a significant mortality surge during the pandemic and persistent demographic disparities.
Triamcinolone Acetonide Shows No Direct Toxicity to Human Knee Cartilage
Laboratory analysis of human tissue suggests triamcinolone reduces degradative enzymes without causing chondrocyte death or matrix loss.
Neural Rhythms in Language and Default-Mode Networks Predict Reading Recall
Combined EEG and MRI data reveal that specific frequency patterns in brain networks correlate with a patient's ability to remember text.
Cartilage Damage Increases Between Primary and Revision ACL Reconstruction
Registry data show a 0.7% increase in the odds of chondral lesions for every month of delay between initial injury and revision surgery.
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Gut Microbiome Signature Identifies Premanifest Parkinson’s Disease Risk
Metagenomic analysis reveals a microbial state in GBA1 carriers that correlates with prodromal symptoms and disease progression.
Childhood Maltreatment Mediates Neural Influence on Depressive Temperament
Hippocampal and insular activity correlate with depressive traits through the subjective appraisal of early life trauma.
Radiographic Bone Texture Analysis Identifies Risk of Femoral Stem Subsidence
Lower texture energy and mean intensity on preoperative radiographs correlate with early implant migration exceeding two millimeters.
Autism Shares Genetic Risk Loci With Diabetes and Heart Disease
Large-scale genomic analysis identifies 100 shared loci linking autism spectrum disorder to metabolic and cardiovascular phenotypes.
Intestinal Permeability Triggers Atrial Fibrillation via JNK2 Activation in Mice
Researchers identified a signaling axis where leaky gut-associated cytokines activate cardiac JNK2 to cause calcium-handling abnormalities.