Cystatin C Discrepancy Predicts Kidney Injury and Death in Cell Therapy
A 30% gap between creatinine and cystatin C filtration estimates identifies high-risk transplant and T-cell therapy candidates.
Adding Tobramycin to Vancomycin Powder Does Not Reduce Tibial Fracture Infections
A randomized trial of 1528 patients shows dual intrawound antibiotic powder offers no benefit over vancomycin alone in high-risk fractures.
Ketamine Increases Brain PDE4 Binding in Rats and Monkeys
Subanesthetic doses rapidly boost cAMP signaling, suggesting a molecular pathway for the drug's fast-acting antidepressant effects.
AI Risk Scores Link to Low-Grade Malignancy Before Clinical Detection
Retrospective analysis shows AI-generated risk scores from prior-year mammograms correlate with tumor grade and invasive lobular pathology.
Preoperative Beta Connectivity Predicts Delirium Risk in Older Surgical Patients
A multicenter study finds reduced brain network communication at baseline identifies vulnerability, though EEG patterns recover by 3 months.
Thalamocortical Connectivity and Immune Dysregulation Linked to Suicidal Ideation in Depression
Researchers identify a caudal temporal thalamus network and peripheral gene expression patterns that distinguish suicidal risk in patients.
Eccentric Cycling Matches Concentric Training for Post-COVID-19 Walking Recovery
An 8-week trial shows eccentric cycling is safe and improves walking distance, though it offers no advantage over concentric exercise.
Genetic Factors Drive Association Between Infections and Tic Disorder Risk
A Swedish cohort study of 3.8 million people suggests shared genetic pleiotropy links infection history to Tourette syndrome risk.
Telehealth Interdisciplinary Care Reduces Symptoms in Persistent Post-Concussion Syndrome
A single-case experimental study shows remote delivery of multi-modal rehabilitation improves functional goals and symptom severity.
Pre-Diagnosis FEV1 Decline Predicts Lung Transplant Survival
The rate of lung function loss in the three months before chronic lung allograft dysfunction onset identifies high-risk patients.
Kennedy Infant Death Accelerated Neonatal Research and Halved Mortality Rates
The 1963 loss of Patrick Bouvier Kennedy catalyzed federal funding that transformed respiratory distress syndrome into a survivable condition.
Lateral Septal PACAP Signaling Modulates Stress and Anxiety in Rodent Models
Localized neuropeptide activity in the lateral septum regulates the neuroendocrine response and shifts behavior toward passive coping.