Immersive Virtual Reality Improves Naming in Chronic Non-Fluent Aphasia
A randomized trial shows immersive therapy yields higher gains in oral motor function and patient enjoyment than conventional methods.
Metabolic Disease Burden Rises in Southern Italy Despite National Declines
A 33-year analysis reveals widening geographic disparities in metabolic health and a growing proportion of unattributable disease burden.
Age, Rhythm, and Low-Flow Duration Predict Neurological Recovery After ECPR
A 14-year cohort study identifies specific predictors to help clinicians select cardiac arrest patients for extracorporeal resuscitation.
GABAA Gain-of-Function Mutation Triggers Seizures via Interneuron Network Collapse in Mice
A study of the GABRB3 p.(Glu77Lys) variant reveals how enhanced inhibitory signaling paradoxically drives cortical hyperexcitability.
Three or More Breast Cancer Foci Increase Specific Mortality Risk
A Swedish cohort study of 71,607 women finds that multifocality independently predicts worse survival despite traditional staging.
Memantine Reduces Premature Atrial Contractions and New-Onset Atrial Fibrillation
A phase 2 trial shows targeting cardiac N-methyl-D-aspartate receptors significantly lowers atrial ectopy and tachyarrhythmia burden.
School Transition Drives Adolescent Well-being Decline More Than Aging
A longitudinal study of 20,910 students shows secondary school transition triggers well-being deficits lasting over two years.
Biceps Tenotomy and Tenodesis Show Moderately Robust Clinical Equivalence
A meta-analysis using the reverse continuous fragility index suggests current evidence for similar outcomes is statistically stable.
Anesthesia Trials Lack Precise Definitions for Perioperative Disruptions
A review of 139 trials finds 60% fail to report how they handle events like surgery cancellations or treatment switching.
French Cohort Study Maps Perinatal Risks for Neurodevelopmental Disorders
A study of 7.4 million children identifies shared and distinct risk factors for ADHD, autism, and intellectual disability.
Endothelial Expansion Drives Vascular Hyalinization in Castleman Disease
Transcriptomic analysis identifies endothelial-B cell crosstalk as a primary driver of stromal dysregulation and systemic inflammation.
Open-Source AI Models Accurately Classify Pediatric Pneumonia on Radiographs
Large language models match physician adjudication of free-text reports, surpassing traditional machine learning in the emergency department.