Twice-Daily Clobetasol 0.05% Reduces Postoperative Inflammation and Pain
Phase 3 trial data show clobetasol propionate ophthalmic suspension achieves high rates of cell clearance without elevating ocular pressure.
Interneuron Loss Fails to Amplify mTOR-Related Seizures in Mice
A two-hit model shows that hippocampal interneuron depletion triggers transient seizures but does not synergize with Pten mutations.
Preexisting Mental Disorders Increase Mortality After Spinal Injury
A cohort study finds younger patients with dual diagnoses face a 17-fold higher mortality risk following traumatic spinal injury.
Emergency Eye Calls Often Mask Acute Stroke and TIA
A Danish cohort study reveals that 7.4% of patients hospitalized for primary ocular complaints were ultimately diagnosed with a stroke.
Low Cardiac Index During Hypotension Increases Acute Kidney Injury Risk
A study of 1,272 cardiac surgery patients finds that hypotension only correlates with renal injury when cardiac index falls below 2.
Rapid Inter-Temporal Seizure Spread Linked to Poor Surgical Outcomes
Deep learning analysis of 275 seizures shows that extensive cortical involvement and rapid propagation correlate with surgical failure.
Systematic Vagus Nerve Stimulation Increases Sensitivity for Detecting Vocal Cord Palsy
Adding a final vagal check after thyroid dissection achieved 100% sensitivity for nerve injury, identifying cases missed by distal testing.
Synuclein Status Shows Limited Correlation With Brain Microstructure in Early Parkinson's
A study of 462 patients finds that positive alpha-synuclein assays do not reflect widespread neurodegeneration on diffusion MRI.
Digital Therapeutic App Reduces Chronic Tinnitus Distress in Randomized Trial
A mobile application delivering cognitive behavioral therapy significantly improved Tinnitus Handicap Inventory scores over 24 weeks.
Platelet Transfusion Linked to Higher Mortality in Sepsis Patients
A retrospective study finds transfusions increase ICU stay and thrombosis risk while failing to raise counts in half of septic patients.
Psychological Factors Predict High-Impact Chronic Pain in Sickle Cell Disease
A prospective study of 90 patients shows that pain catastrophizing and low self-efficacy correlate with sustained functional impairment.
Cell-Specific Gene Expression Analysis Identifies Schizophrenia Risk Drivers
Researchers mapped 466 causal genes across eight brain cell types, pinpointing MAU2 and PPP1R13B as high-priority therapeutic targets.