C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.
Prophylactic Antiemetics Fail to Reduce Opioid-Induced Nausea in Prehospital Trauma
A prospective study of 205 HEMS patients shows no benefit for routine intravenous ondansetron or isopropanol aromatherapy.
Awake Mapping for Grade 2 Glioma Reduces Intractable Epilepsy Burden
Extensive resection of IDH-mutant tumors improves seizure freedom and return-to-work rates, particularly for insular lesions.
Prenatal SRI Exposure Linked to Altered Fetal Brain and Placental Growth
MRI data show reduced hippocampal volume and cortical folding in fetuses exposed to antidepressants or high maternal depression scores.
Taekwondo and Football 5-a-Side Show Highest Injury Risk at Paris Paralympics
Prospective surveillance of 4,450 athletes reveals significant sex-based and sport-specific variations in injury burden and illness rates.
Ivermectin Fails to Improve Outcomes in Hospitalized COVID-19 Patients
A randomized trial shows no benefit for organ support-free days or survival in critically and noncritically ill patients.
Freezing of Gait Linked to Maladaptive Task Prioritization in Parkinson’s
Patients with freezing of gait maintain walking speed by sacrificing manual task accuracy, driven by impaired theta-band neural activity.
Iron Overload Linked to High Rates of Hypogonadism and Infertility
A systematic review of over 3,000 patients finds nearly half of men and women face severe reproductive impairment from iron toxicity.
AI Protocol Support Shows 75% Accuracy in Simulated Prehospital Emergencies
A simulation study using Gemini 2.5 Flash found significant gaps in pediatric cardiac arrest recommendations despite overall accuracy.
Iron and Lead Levels Linked to Brain Microstructure in Autistic Language Delay
Low serum iron and high lead levels correlate with reduced neurite complexity in language-processing regions of children with autism.
Clinician Recommendation Increases Patient Willingness to Use Behavioral Pain Strategies
A survey of 455 oncology outpatients finds that provider endorsement is the strongest motivator for adopting behavioral health interventions.
Intravenous Ketamine Reduces Suicidal Ideation and Depression for One Month
A meta-analysis of 26 trials shows rapid symptom relief within four hours and sustained antisuicidal effects following intravenous infusion.