TSPO Deletion Reduces Cortical Spreading Depolarization in Mice
A new study in mice suggests that modulating translocator protein 18 kDa may influence CSD generation and associated neurovascular and inflammatory re
Low-Dose IL-2 Fails to Expand Tregs After Alemtuzumab in RRMS
A mechanistic study reveals that low-dose interleukin-2 alone does not boost regulatory T cells in alemtuzumab-treated multiple sclerosis patients.
Vertebrobasilar and Middle Cerebral Aneurysms Carry Highest Case Fatality Rates
A population-based study of 13,470 cases shows that aneurysm location significantly influences sudden death and 30-day mortality risks.
MSK1 Mediates BDNF Signaling in Striatal Development, Affecting Psychiatric-Relevant Behaviors
A new study identifies mitogen- and stress-activated kinase 1 (MSK1) as a key mediator in brain-derived neurotrophic factor (BDNF) pathways critical.
Inhaled Treprostinil Slows Lung Function Decline, Reduces Clinical Worsening in IPF
A phase 3 trial demonstrates that inhaled treprostinil significantly mitigates FVC reduction and clinical deterioration in patients with idiopathic.
Validating Generative AI Therapeutics: A Proposed Framework for Clinical Integration
A new framework outlines a multi-stage validation process to ensure the safety and efficacy of generative AI agents in mental health care.
Cerebellar iTBS Improves Post-Stroke Cognition via Dentate Nucleus-Ventromedial Thalamus Pathway
A mouse model study identifies the specific neural circuit mediating the cognitive benefits of intermittent theta-burst stimulation after stroke.
Fine Particulate Matter Increases Risk of Recurrent Stroke and Death
A national cohort study finds that PM2.5 exposure nearly triples the risk of stroke recurrence and secondary cardiovascular events.
Cathepsin S Links to Tissue Remodeling, Severity in Chronic Rhinosinusitis with Nasal Polyps
Integrative multi-omics analysis identifies cathepsin S (CTSS) as a key mediator of tissue remodeling and disease severity in CRSwNP.
4% Tetrasodium EDTA Lock Reduces CVAD Complications in ICU Adults
A multicenter, cluster-randomized trial shows 4% t-EDTA locking fluid decreases a composite of CVAD-associated events, primarily catheter occlusions.
VSED with Hospice: Clinical Course, Symptom Management, and Patient Demographics
A case series details the clinical trajectory, symptom burden, and care needs of patients choosing voluntarily stopping eating and drinking.
Tezepelumab Reduces Oral Corticosteroid Use in Severe Asthma
A phase 3 trial demonstrates that tezepelumab significantly lowers daily oral corticosteroid dose in adults with severe, OCS-dependent asthma.