Early Famine Exposure Linked to Accelerated Functional Decline in Older Adults
Nutritional deprivation during fetal and preschool development increases the risk of rapid intrinsic capacity deterioration by over 50 percent.
Peri-Ictal MRI Abnormalities Predict 60% Seizure Risk After Status Epilepticus
Transient DWI and FLAIR changes within 48 hours of a first status epilepticus episode identify patients at high risk for epilepsy.
Lactate Enzyme Overexpression Enhances Remyelination in Animal Models
Restoring glycolysis and lactate production in oligodendrocyte precursors overcomes epigenetic silencing to stimulate myelin repair.
Inhaled Methoxyflurane Avoids IV Sedation in Half of Prehospital Fractures
Inhaled methoxyflurane successfully facilitated prehospital limb reduction in 54% of patients without requiring intravenous sedation.
Mental Health Gains Tied to Cessation, Not E-Cigarette Switching
A large study links complete cessation to better mental health over time, a benefit not seen in those who switch to e-cigarettes.
Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
CTA Plaque-RADS Predicts Ipsilateral Recurrence in Embolic Stroke
A standardized scoring system for nonstenotic carotid plaques identifies a distinct ESUS subgroup with a threefold higher risk of recurrence.
US Adult Obesity Projected to Reach 47 Percent by 2035
An analysis of over 11 million adults reveals severe racial and geographic disparities as obesity rates continue to climb nationwide.
Maternal Depressive Symptoms Nearly Double Preeclampsia Risk
A meta-analysis of over 44,000 pregnancies shows early depressive symptoms significantly elevate the risk of hypertensive complications.
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.
Consensus Algorithm Standardizes Rural Air Medical Transport Triage
A multidisciplinary panel used a Delphi survey to identify 18 patient factors and 6 interventions that warrant helicopter transport.
Oral Celecoxib and Ciprofloxacin Slow Functional Decline in ALS
A phase 2b trial shows the fixed-dose combination is safe and reduces the risk of severe complications over 18 months in early-stage ALS.