Rising Depressive Symptoms Precede Cardiovascular Disease by Over a Decade
A longitudinal analysis of nearly 50,000 adults identifies a sustained increase in depressive symptoms as a long-term prodromal phase of CVD.
Early DHEA Levels Predict Depression in Adolescent Males but Not Females
A longitudinal study finds that while DHEA at age nine increases risk for males, adrenal hormones do not explain higher female prevalence.
Home-Based Prefrontal Cortex Stimulation Reduces Subjective Stress Appraisal
A feasibility study of self-administered tDCS shows high adherence and safety, though physiological stress markers remained unchanged.
Four Months of Fingolimod Does Not Improve Anxiety or Depression in MS
A prospective study of 61 patients with relapsing-remitting MS found no significant changes in mood scores after initiating fingolimod.
Students With Moderate Distress Show High Rate of Worsening
A 10-month analysis finds this group is a key target for intervention, with problematic internet use predicting negative outcomes.
Australian Military Abandons Stratified Suicide Risk for Collaborative Safety Planning
A system-wide initiative removed low, medium, and high risk labels, training over 72,000 personnel in member-centered risk formulation.
MRI Tracks Hippocampal Damage and Recovery in Rat Epilepsy Model
A longitudinal study in rats reveals acute hippocampal volume loss after status epilepticus, followed by partial recovery over 30 days.
Activities Counter Negative Affect in Depressed, Anhedonic Youth
Real-world data show leisure and social company improve mood primarily by decreasing negative affect, not by increasing positive affect.
Adolescent Nicotine Rewires Brain Circuitry to Boost Opioid Reward in Mice
Early nicotine exposure alters GABA signaling in the ventral tegmental area, amplifying the rewarding effects of morphine in adult mice.
Menstrual Cycle Phases Alter Brain Reactivity to Drug Cues
Functional MRI reveals that estrogen heightens cue-induced craving in women with substance use disorders, while progesterone blunts it.
Dopamine Blockade Attenuates Morphine Analgesia in Rat Hippocampus
Blocking D1 dopamine receptors in the dentate gyrus significantly reduces the pain-relieving effects of morphine in an animal model.
Alexithymia and Poor Coping Link Trauma to Self-Injury in Depressed Youth
An inability to process emotions drives maladaptive coping, forming a chain reaction that connects early trauma to adolescent self-harm.