Nicotine Rewires Habenular Circuits in Mice, Altering Food Motivation
Chronic nicotine exposure in mice disrupts top-down control of the LDT-VTA cholinergic axis, driving exaggerated food-seeking behavior.
Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
Inhibiting RhoA in Rat Prefrontal Cortex Reduces Morphine Dependence
Blocking the RhoA pathway in rats reduces opioid-induced neuroplasticity and limits glutamate spillover, offering a specific addiction target.
Epigenetic Target HDAC5 Reduces Environment-Triggered Cocaine Seeking in Rats
In a rat model, overexpressing the enzyme HDAC5 in the prelimbic cortex shifted synaptic balance to suppress context-driven cocaine seeking.
Cognitive Status Remains Key Predictor of Dementia Risk Alongside p-tau181
ARIC data show that while p-tau181 is prognostic, the absolute risk of dementia remains low in cognitively unimpaired individuals.
Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.
Social Anxiety Affects Nearly Half of College Students
An analysis of 5,996 students reveals a 47.9% incidence of social anxiety, with gender, grade, and physical activity as top predictors.
Caffeinated Coffee and Tea Lower Dementia Risk; Decaf Shows No Benefit
A 43-year prospective study of 131,821 adults reveals that 2 to 3 cups of caffeinated coffee daily significantly reduces incident dementia.
Cross-Ancestry Analysis Identifies Shared Genetic Risk for Major Psychiatric Disorders
Researchers identified 403 genetic loci and specific cellular pathways common to schizophrenia, bipolar disorder, and depression.
Glioblastoma Cells Hijack Fetal Neural Stem Cell Motors to Spread
Glioblastoma cells use the same dynein-driven and actomyosin-dependent motors as fetal neural stem cells to invade surrounding tissue.
Apps for Alcohol Use Do Not Improve Mood Beyond Standard Care
In a randomized trial, digital tools added to standard care did not further reduce depression or anxiety in adults with alcohol dependence.
Intracortical Implant Enables Paralyzed Patients to Type 22 Words Per Minute
By decoding attempted finger movements, a neuroprosthesis allows patients with tetraplegia to type on a virtual QWERTY keyboard.