Transcriptional Map Identifies 37 Interneuron Subtypes in Human Prefrontal Cortex
Researchers used single-nucleus RNA sequencing to define molecular signatures of somatostatin and parvalbumin cells in healthy adults.
Cryo-EM Maps Molecular Shift Producing Thrombin in Coagulation Cascade
Researchers identify a 20-angstrom reorientation required for the final proteolytic cleavage of prothrombin into active thrombin.
Triamcinolone Acetonide Shows No Direct Toxicity to Human Knee Cartilage
Laboratory analysis of human tissue suggests triamcinolone reduces degradative enzymes without causing chondrocyte death or matrix loss.
Lactate Enzyme Overexpression Enhances Remyelination in Animal Models
Restoring glycolysis and lactate production in oligodendrocyte precursors overcomes epigenetic silencing to stimulate myelin repair.
Glioblastoma Cells Hijack Fetal Neural Stem Cell Motors to Spread
Glioblastoma cells use the same dynein-driven and actomyosin-dependent motors as fetal neural stem cells to invade surrounding tissue.
Inhibiting USP22 Halts Periodontitis-Linked Brain Inflammation in Mice
Knocking down the enzyme USP22 in mice prevents the periodontal pathogen P. gingivalis from degrading blood-brain barrier tight junctions.