The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Betaine Reverses Placental Hypoxia and Growth Restriction in Mouse Model of Depression
High-dose betaine restores VEGF and BDNF signaling to improve placental vascularity and fetal weight in stressed mice.
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High-Dose Influenza Vaccine Linked to Lower Alzheimer Risk in Seniors
A retrospective cohort study of 164,797 adults finds high-dose vaccination reduces dementia risk more than standard-dose formulations.
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Neuroimaging Model Distinguishes Functional Constipation Subtypes with 89% Accuracy
Machine learning analysis of brain structure and white matter tracts identifies comorbid anxiety and depression in chronic constipation.
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Group Metacognitive Therapy Reduces Pediatric OCD Symptoms Despite Comorbidities
A naturalistic study of 37 youth shows an 81.1% response rate and significant symptom reduction across complex diagnostic profiles.
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Digital Exercise and Interoceptive Training Lower Acute Depression Scores in Young Adults
A randomized trial found significant short-term symptom reduction, though benefits did not persist at one- or three-month follow-up.
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Group CBT Reduces Hostile Attribution Bias in Young Adults With ASD Traits
A pilot study finds that targeting social cognitive distortions improves communication and quality of life through distinct pathways.
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Group Cognitive Therapy Reduces Negative Symptoms in Early Psychosis
A pilot trial shows rumination-focused therapy added to standard care significantly improves negative symptoms and repetitive thinking.
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Prenatal Distress Linked to Altered Cortical Folding and Child Behavior
Second-trimester maternal anxiety correlates with reduced gyrification and increased social withdrawal in children at age eight.
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Maternal Posttraumatic Stress Blunts Neural Response to Infant Distress
Reduced activity in brain regions governing salience and emotion regulation correlates with lower maternal sensitivity in the first year.
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Mental Fatigue Linked to Sensory Hypersensitivity in Stroke Survivors
A cross-sectional study finds 41% of stroke patients experience both symptoms, with sensory sensitivity tied specifically to mental exhaustion.
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Aging Rats Show Inverted Hypothalamic Response to Ghrelin Signaling
Age-related increases in ghrelin receptor expression coincide with a shift from neuronal activation to inhibition in the dorsomedial nucleus.
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Primary Care Underutilizes Specialist-Recommended Medications for ME/CFS
A retrospective study of 571 patients shows limited use of targeted pharmacotherapy and high reliance on dietary supplements.
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Antipsychotics and Antiemetics Drive Pediatric Drug-Induced Dystonia
A study of 79 children finds most reactions occur within 72 hours of exposure and respond rapidly to parenteral biperiden.
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Postural Control Deficits Drive Gait Dysfunction in Huntington's Disease
Wearable sensor data show that balance impairments explain up to 39 percent of gait variance and emerge during the pre-manifest stage.
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Delaying Substance Use Until Age 21 Linked to 83% Lower Polysubstance Risk
A national survey of 92,233 adults shows that early initiation before age 18 significantly increases the risk of multiple concurrent addictions.
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Brain Fluoxetine Levels Fail to Predict Clinical Response in Youth
Neurometabolic markers of neuronal integrity, not drug concentrations, correlate with symptom improvement in adolescent depression.
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Intranasal Ketamine Reduces Existential Distress in Advanced Cancer Patients
Secondary analysis shows three doses of intranasal ketamine improve death-related anxiety and existential well-being in palliative care.
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Visual Cortex Pathways Form Adult-Like Architecture Before Birth
MRI data from 584 neonates show that dorsal and ventral streams develop at different rates during the third trimester.
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Normative Modeling Maps Individual Brain Deviations in Traumatic Brain Injury
Patient-specific MRI analysis reveals unique structural changes that traditional group-level averages often obscure in moderate-to-severe TBI.
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Behavioral Activation Reduces Pain During Smoking Cessation in Depressed Adults
A secondary analysis finds that behavioral activation therapy significantly lowers bodily pain scores compared to standard cessation care.
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Sympathy Mediates Nursing Care Tendencies in Alcohol Use Disorder
A cross-sectional study of 348 nurses finds that sympathy, not fear or anger, drives helping behaviors despite perceived patient stigma.
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Digital and Primary Care Intervention Reduces Adolescent Depressive Symptoms in Slums
A randomized trial in India shows a multimedia campaign and digital tools improve mental health literacy and lower PHQ-9 scores.
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Cognitive Reserve Delays Symptom Onset in Dominantly Inherited Alzheimer Disease
Higher cognitive reserve is associated with a fourfold increase in the odds of remaining asymptomatic despite genetic risk factors.
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Medically Assisted Reproduction Shows No Independent Link to Perinatal Distress
A prospective cohort study of 9,289 women found that baseline characteristics, not conception mode, drive mental health outcomes.