The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Prefrontal Hypoactivation and Time Distortion Linked to Adolescent Self-Injury
Adolescents who self-harm show reduced left dorsolateral prefrontal cortex activity and a distinct inability to accurately estimate time.
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Early Postnatal Oxytocin Restores Hippocampal Plasticity in Fragile X Mice
Intranasal administration during a specific developmental window permanently corrects episodic memory and synaptic deficits in Fmr1-knockout mice.
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GLP-1 Receptor Agonists Reduce Psoriasis Severity in Patients With Obesity
A National Psoriasis Foundation primer details how incretin therapies lower skin scores and systemic inflammatory markers.
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Comparative Transcriptomics Map Shared Molecular Pathways in Parkinsonian Disorders
A large-scale analysis of 977 brain samples identifies core failures in protein homeostasis and mitochondrial metabolism across syndromes.
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Intravenous Tocilizumab Stabilizes Severe Pediatric Neuroinflammation Within 72 Hours
A retrospective study shows rapid clinical improvement and intracranial pressure reduction in children with refractory CNS inflammation.
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2C-B Shows Empathogenic and Psychedelic Effects with Low Cardiovascular Strain
A crossover trial compares 30 mg of 2C-B to MDMA and psilocybin, finding similar emotional empathy and a shorter five-hour duration.
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Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
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Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
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MRI Index Quantifies Alzheimer’s Pattern to Predict Dementia Onset
A structural brain vulnerability index identifies early neurodegeneration and predicts conversion from mild cognitive impairment.
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Prenatal Depression Does Not Alter Infant Oral Microbiome at Birth
A cohort study of 324 mother-infant pairs finds no link between maternal affective symptoms and neonatal microbial diversity or composition.
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Lithuanian Liebowitz Social Anxiety Scale Shows High Reliability in Young Adults
A validation study of the self-report version finds strong internal consistency but suggests total scores are most robust for assessment.
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Plasma Tau and MRI Mismatch Identifies Rapid Alzheimer's Decline
Disproportionate brain atrophy relative to plasma ptau217 levels signals a vulnerable phenotype with faster cognitive loss and co-pathology.
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All of Us Program Links 14 Years of Wearable Data to Clinical Records
A massive dataset connects Fitbit metrics from 59,000 participants to genomics and electronic health records for longitudinal research.
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Chronic and Social Needs Linked to High School Absenteeism
A national study finds children with both chronic health conditions and social instability face a 9.4% risk of missing 11 or more school days.
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Gut Microbiome Linked to Macrocephaly in NF1 Mouse Model
Sex-specific microbial signatures correlate with brain size and autism-like behaviors in mice with Neurofibromatosis type 1 mutations.
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Low CSF Amyloid-Beta Predicts Intracranial Hemorrhage in CAA Patients
Low levels of amyloid-beta 40 and 42 in cerebrospinal fluid are associated with a sevenfold increase in future symptomatic bleeding risk.
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Genetic Risk Factors Directly Link to Pediatric Suicidality Independent of Symptoms
Polygenic scores for internalizing and externalizing traits reveal direct and mediated pathways to suicidal ideation and attempts in youth.
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Astrocytic Hemichannel Overactivity Drives Prefrontal Circuit Deficits in Schizophrenia Models
Elevated connexin 43 in the prefrontal cortex triggers excessive glutamate release, offering a potential non-neuronal therapeutic target.
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Responsive Neurostimulation Reduces Focal Seizures by 82% at Three Years
A prospective postapproval study of 324 adults shows real-world seizure reduction exceeds initial clinical trial results.
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GDF-15 Predicts Depressive Symptoms in Adults Aged 72 and Older
A longitudinal study finds that growth differentiation factor 15 correlates with depression severity only in geriatric populations.
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Caregiver Strain Mediates Alpha Wave Activity in Children With ADHD
Subjective internalized caregiver stress links clinical attention deficits to posterior alpha power, suggesting environmental modulation.
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Basal Ganglia Perivascular Spaces Predict Long-Term Executive and Visuospatial Decline
A decade-long study identifies perivascular spaces as an independent marker of cognitive deterioration, distinct from other vascular lesions.
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First-Time Seizure Linked to Increased Risk of Systemic and Neurological Cancer
A Danish cohort study finds a fivefold increase in overall cancer risk within one year of an initial seizure in adults.
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Subliminal Threat Cues Trigger Sustained Social Avoidance in Women
Eye-tracking data reveals that unconscious perception of anger or disgust leads to reduced visual engagement with subsequent happy faces.