The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Early Language and Motor Skills Predict Adolescent Independence in Autism
A decade-long longitudinal study identifies preschool markers that determine functional daily living outcomes for autistic teenagers.
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Water Access and Vaccination Linked to Lower Pediatric HIV Mortality
Meta-regression of 67 cohorts identifies water access, pneumococcal vaccination, and maternal education as key predictors of survival.
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ED Boarding Times for Older Adults with Dementia Surged Between 2015 and 2022
A national analysis shows mean boarding times for geriatric patients more than doubled since 2018, reaching 501 minutes for those with dementia.
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CEP41 Mutations Alter Cortical Neuron Ratios in Human Organoid Models
The R242H mutation shortens primary cilia and disrupts the balance of excitatory and inhibitory neurons during brain development.
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Adolescent Depression Linked to Declining Amygdala-Prefrontal Connectivity
Longitudinal imaging shows that escalating depressive symptoms correlate with weakening frontolimbic links during emotion regulation.
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Critical Illness Linked to Significant Income Loss and Unemployment
A nationwide cohort study of 582,341 survivors reveals that over 10% face catastrophic financial decline despite universal coverage.
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Type 2 Diabetes Linked to Reduced Effort-Based Motivation Unchanged by Semaglutide
A computational study finds metabolic dysfunction drives a cognitive shift toward energy conservation regardless of GLP-1 agonist use.
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Pure Autonomic Failure Carries 5% Annual Risk of Central Phenoconversion
A meta-analysis identifies hyposmia and sleep disturbances as key predictors of progression to Parkinson disease or multiple system atrophy.
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Microglial Activation Disrupts Hippocampal Memory Consolidation in Aged Mice After Surgery
Surgical stress triggers neuroinflammation that inhibits CA3 to CA1 signaling, reducing sharp-wave ripples essential for memory.
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Heartbeat Evoked Potential Lacks Consistency for Clinical Use
A meta-analysis finds that methodological variability prevents using this neural marker of interoception as a reliable diagnostic tool.
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Veterans Hospitalized for Alcohol Use Disorder Often Miss Medication Initiation Opportunities
A study of 29,041 hospitalizations found that only 30.8% of veterans received medications like naltrexone during or shortly after discharge.
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PREVENT and SCORE2 Equations Accurately Predict Global Cardiovascular Risk
A validation study of 6.4 million people confirms these risk models perform well across North America, Europe, and Asia.
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Hippocampal Ripples Coordinate Cortical Planning Sequences in Epilepsy Patients
High-resolution intracranial recordings show that hippocampal ripples and neural replay drive the assembly of complex cognitive solutions.
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Psychotherapy Shows Large, Durable Effects in Treatment-Resistant Depression
A reanalysis of trial data suggests clinical gains stem from simultaneous psychological shifts rather than sequential changes in defense.
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Lifestyle and Psychological Factors Predict Pandemic-Era Depression in Older Adults
A longitudinal study identifies sleep disturbances and reduced physical activity as key drivers of increased depressive symptoms.
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Stable Social Media Addiction Symptoms Link to Adolescent Anxiety and Depression
Longitudinal network analysis identifies tolerance and conflict as core drivers of digital dependency and comorbid internalizing disorders.
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US Neurology Wait Times Average 50 Days Following Primary Care Referral
A retrospective analysis of 114,034 patients identifies significant delays for multiple sclerosis and regional disparities in access.
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24-Hour Blood Pressure Variability Linked to Cognitive Decline and Brain Aging
Fluctuations in ambulatory blood pressure correlate with impaired executive function and blood-brain barrier leakage in older adults.
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Cutaneous pTDP-43 Deposits Distinguish ALS From Other Neuropathies
Skin and tongue biopsies detect phosphorylated TDP-43 pathology that correlates with clinical disease stage in patients with ALS.
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Family Functioning Influences Prenatal Bonding Directly and via Depressive Symptoms
A multicenter study of 261 pregnant women shows that family dynamics shape the emotional quality of maternal-fetal attachment.
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Condition-Based Monitoring Reduces Depression Incidence and Improves Treatment Response
A multi-domain framework utilizing C-reactive protein and autonomic monitoring aims to bridge the intervention gap in preventive psychiatry.
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Telehealth Hypnotic Cognitive Therapy Reduces Chronic Pain After Spinal Cord Injury
A randomized trial demonstrates that remote delivery of hypnotic cognitive therapy significantly lowers pain intensity and depression.
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RNA Interference Normalizes PAI-1 Levels and Prolongs Lifespan in Murine Models
A single dose of siRNA-lipid nanoparticles achieved 90% knockdown of plasma PAI-1, reducing thrombus weight and increasing survival in mice.
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Triglyceride-Glucose Index Linked to Cognitive Deficits in Depression and Diabetes
A high triglyceride-glucose index correlates with cognitive impairment via inflammatory and tau-related pathways in comorbid patients.