The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Brain FAAH Levels Rise During Short-Term Cannabis Abstinence
PET imaging shows enzyme increases in the ventral striatum correlate with depression and impulsivity during early withdrawal.
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Perinatal Cash Transfers Linked to 32% Drop in Infant Maltreatment Reports
A study of Flint's Rx Kids program shows unconditional cash support significantly reduces child protective services investigations.
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Advanced Paternal Age Increases Autism Risk in Grandchildren via Female Lineage
A registry study of 12.6 million people shows that a grandfather's age at his daughter's birth influences his grandchildren's autism risk.
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Preexisting Mental Disorders Increase Mortality After Spinal Injury
A cohort study finds younger patients with dual diagnoses face a 17-fold higher mortality risk following traumatic spinal injury.
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Synuclein Status Shows Limited Correlation With Brain Microstructure in Early Parkinson's
A study of 462 patients finds that positive alpha-synuclein assays do not reflect widespread neurodegeneration on diffusion MRI.
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Digital Therapeutic App Reduces Chronic Tinnitus Distress in Randomized Trial
A mobile application delivering cognitive behavioral therapy significantly improved Tinnitus Handicap Inventory scores over 24 weeks.
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Psychological Factors Predict High-Impact Chronic Pain in Sickle Cell Disease
A prospective study of 90 patients shows that pain catastrophizing and low self-efficacy correlate with sustained functional impairment.
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Cell-Specific Gene Expression Analysis Identifies Schizophrenia Risk Drivers
Researchers mapped 466 causal genes across eight brain cell types, pinpointing MAU2 and PPP1R13B as high-priority therapeutic targets.
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C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.
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Awake Mapping for Grade 2 Glioma Reduces Intractable Epilepsy Burden
Extensive resection of IDH-mutant tumors improves seizure freedom and return-to-work rates, particularly for insular lesions.
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Prenatal SRI Exposure Linked to Altered Fetal Brain and Placental Growth
MRI data show reduced hippocampal volume and cortical folding in fetuses exposed to antidepressants or high maternal depression scores.
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Freezing of Gait Linked to Maladaptive Task Prioritization in Parkinson’s
Patients with freezing of gait maintain walking speed by sacrificing manual task accuracy, driven by impaired theta-band neural activity.
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Iron Overload Linked to High Rates of Hypogonadism and Infertility
A systematic review of over 3,000 patients finds nearly half of men and women face severe reproductive impairment from iron toxicity.
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Iron and Lead Levels Linked to Brain Microstructure in Autistic Language Delay
Low serum iron and high lead levels correlate with reduced neurite complexity in language-processing regions of children with autism.
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Clinician Recommendation Increases Patient Willingness to Use Behavioral Pain Strategies
A survey of 455 oncology outpatients finds that provider endorsement is the strongest motivator for adopting behavioral health interventions.
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Intravenous Ketamine Reduces Suicidal Ideation and Depression for One Month
A meta-analysis of 26 trials shows rapid symptom relief within four hours and sustained antisuicidal effects following intravenous infusion.
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Apathy Mechanisms Differ Between Alzheimer's and Parkinson's Disease
Computational modeling reveals distinct effort-sensitivity profiles and neural signatures for motivational loss across neurodegenerative types.
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Auditory Temporal Processing Linked to Language Deficits in Autistic Youth
Specific auditory processing sub-types correlate with expressive language and the recognition of vocal emotional cues in children.
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Medial Temporal Lesions Impair Memory Precision Rather Than Capacity
Post-surgical data from 40 epilepsy patients show hippocampal damage increases recall variability without reducing the total items retained.
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Identical EEG Bursts Signal Severe Loss of Brain Network Complexity
A multi-model study identifies identical burst suppression as a default state of simplified excitatory networks in irreversible coma.
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Cyclothymic and Anxious Temperaments Predict Perinatal Depression Risk
A cross-sectional study identifies specific affective profiles and psychiatric history as independent predictors of perinatal mood disorders.
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Cerebral Amyloid Angiopathy Increases Dementia Risk in Memory Clinics
A five-year study of 2,136 patients shows that radiologic markers of amyloid angiopathy predict progression from mild symptoms to dementia.
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Intracranial Recording Maps Immediate and Sustained Effects of Brain Stimulation
Direct neural recordings in humans and primates reveal that magnetic pulses trigger cellular excitation in 2 milliseconds.
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Autologous Mesenchymal Cells Reduce Neuroinflammation in Chronic Brain Injury
A Phase 1/2a trial shows intravenous stromal cells improve white matter integrity and reduce immune cell density in the chronic TBI brain.