Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
Randomized Controlled Trial
Dihydroartemisinin-Piperaquine Reduces Early Plasmodium vivax Recurrence Compared With Chloroquine
A randomized trial in Brazil shows dihydroartemisinin-piperaquine effectively prevents early malaria recurrence when primaquine is delayed.
Randomized Controlled Trial
Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.
Randomized Controlled Trial
Single Sigmoidoscopy Reduces Male Colorectal Cancer Death at 23 Years
A Norwegian trial shows a single screening sigmoidoscopy provides long-term protection for men, but mortality benefits are absent in women.
Randomized Controlled Trial
Digoxin Reduces Heart Failure Risk in Rheumatic Heart Disease
A randomized trial in India shows low-dose digoxin decreases the composite risk of death or worsening heart failure by 18 percent.
Randomized Controlled Trial
Low-Dose Digoxin Fails to Reduce Heart Failure Events in Randomized Trial
A study of 1,001 patients found targeting low serum concentrations did not significantly lower mortality or urgent hospital visits.
Randomized Controlled Trial
Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
Randomized Controlled Trial
CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.
Non-Randomized Controlled Trial
NXT007 Reaches Nonhemophilic Factor VIII Levels in Severe Hemophilia A
A phase 1/2 trial shows monthly subcutaneous NXT007 achieves factor activity above 40 IU/dL and eliminates bleeds at higher doses.
Randomized Controlled Trial
Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
Randomized Controlled Trial
Magnetic Seizure Therapy Limits Memory Loss in Bipolar Depression Trial
A randomized pilot study shows magnetic seizure therapy matches the efficacy of ultrabrief ECT while reducing cognitive adverse effects.
Non-Randomized Controlled Trial
Prostate SBRT Maintains 90% Relapse-Free Survival at Ten Years
A multi-center trial of 310 patients shows low- and intermediate-risk prostate cancer control remains durable with minimal late toxicity.
Randomized Controlled Trial
Twice-Daily Clobetasol 0.05% Reduces Postoperative Inflammation and Pain
Phase 3 trial data show clobetasol propionate ophthalmic suspension achieves high rates of cell clearance without elevating ocular pressure.
Randomized Controlled Trial
Digital Therapeutic App Reduces Chronic Tinnitus Distress in Randomized Trial
A mobile application delivering cognitive behavioral therapy significantly improved Tinnitus Handicap Inventory scores over 24 weeks.
Non-Randomized Controlled Trial
Prophylactic Antiemetics Fail to Reduce Opioid-Induced Nausea in Prehospital Trauma
A prospective study of 205 HEMS patients shows no benefit for routine intravenous ondansetron or isopropanol aromatherapy.
Randomized Controlled Trial
Ivermectin Fails to Improve Outcomes in Hospitalized COVID-19 Patients
A randomized trial shows no benefit for organ support-free days or survival in critically and noncritically ill patients.
Randomized Controlled Trial
Strengthening and Stretching Yield Similar Quality of Life Gains in Hip Impingement
A randomized trial finds targeted strengthening improves pain perception and muscle force more than stretching, despite equal quality of life scores.
Randomized Controlled Trial
Robotic Kidney Transplant Reduces Complication Rates in Randomized Trial
A Danish study finds robot-assisted surgery lowers major and vascular complications by approximately 10 percent compared to open surgery.
Non-Randomized Controlled Trial
Nerve Monitoring Reduces Neurapraxia and Dissection Time in Complex Facelifts
A prospective study of 200 patients shows intraoperative monitoring prevents nerve injury and halves operative time in secondary cases.
Non-Randomized Controlled Trial
Autologous Mesenchymal Cells Reduce Neuroinflammation in Chronic Brain Injury
A Phase 1/2a trial shows intravenous stromal cells improve white matter integrity and reduce immune cell density in the chronic TBI brain.
Randomized Controlled Trial
Individualized Algorithm Lowers Achilles Rerupture Risk and Limits Unnecessary Surgery
The CARTA protocol uses ultrasound criteria to select patients for surgery, reducing reruptures by 73% compared to non-operative management.
Randomized Controlled Trial
Higher Ivermectin Dose Does Not Improve Severe Scabies Cure Rates
A randomized trial shows 400 μg/kg of ivermectin plus permethrin is not superior to the standard 200 μg/kg dose for crusted scabies.
Randomized Controlled Trial
Ketamine Shows No Sustained Hemodynamic Advantage Over Propofol During Intubation
A randomized trial in critically ill patients found that ketamine-induced blood pressure benefits were transient and did not improve survival.
Non-Randomized Controlled Trial
Prophylactic Lymphatic Reconstruction Reduces Lymphedema Risk in Gynecologic Cancer
Simultaneous lymph node-to-vein anastomosis lowered the one-year incidence of lower extremity lymphedema from 49 percent to 8 percent.
Randomized Controlled Trial
MRNA Influenza Vaccine Reduces Infection Risk in Adults Over 50
A phase 3 trial found mRNA-1010 superior to standard vaccines, though it caused more frequent transient systemic reactions.
Randomized Controlled Trial
Mindfulness Adjunct Lowers Anxiety Scores in Medicated Adults With GAD
An 8-week mindfulness program added to pharmacotherapy improved clinician-rated anxiety, sleep quality, and psychosocial functioning.
Randomized Controlled Trial
One-Liter PEG-Ascorbate Improves High-Quality Inpatient Bowel Cleansing
A randomized trial shows very low-volume preparation yields superior right-colon visualization compared to 2-liter and 4-liter regimens.
Randomized Controlled Trial
Prefrontal Stimulation Amplifies Placebo Mood Response in Depression
Intermittent theta burst stimulation of the dorsomedial prefrontal cortex modulates the default mode network to enhance expectancy effects.
Non-Randomized Controlled Trial
Automated Ventilation Maintains Target Minute Volume in Helicopter Rescue Simulation
A crossover study shows automated ventilators achieve target ventilation more consistently than manual bagging during short-haul transport.
Randomized Controlled Trial
Manual Pressure Augmentation During Defibrillation Does Not Improve Survival
A randomized trial found that while manual pressure reduces transthoracic impedance, it does not increase survival to hospital discharge.
Randomized Controlled Trial
Restrictive Sepsis Resuscitation Shows No Long-Term Functional Deficits
A randomized trial finds similar cognitive and physical outcomes at 12 months for restrictive versus liberal fluid strategies in sepsis.