Counterconditioning Stabilizes Neural Safety Signals in PTSD
Functional MRI shows pairing threat stimuli with positive outcomes reinforces safety patterns in the ventromedial prefrontal cortex.
Prenatal THC and Stress Synergistically Impair Maternal Care and Offspring Neurodevelopment
A mouse study finds combined prenatal exposures disrupt adolescent gene expression and behavior in a sex-specific manner.
Mouse Study Identifies ACC Genetic Networks Driving Pain-Induced Anxiodepression
A regulatory axis involving five hub mRNAs and specific synaptic signaling pathways in the anterior cingulate cortex mediates mood shifts.
Prefrontal Gene Networks Predict Fentanyl Escalation in Rat Models
Researchers identified specific ion channel and synaptic signaling pathways in the prefrontal cortex linked to compulsive opioid intake.
Acetate Supplementation May Reduce Psychotropic-Induced Weight Gain and Dyslipidemia
A case-series shows delayed-release acetate capsules improve metabolic markers and shift gut microbiota toward butyrate-producing bacteria.
Systemic Inflammation Triggers Sex-Specific Social Proximity Changes in Mice
While both sexes show similar sickness behaviors, acute immune activation specifically reduces social distance in male mice.
Breath Analysis Distinguishes Alzheimer’s Disease From Other Dementias
A diagnostic model using exhaled volatile organic compounds identifies Alzheimer’s disease with 93% accuracy in a 241-patient cohort.
Ketamine Increases Brain PDE4 Binding in Rats and Monkeys
Subanesthetic doses rapidly boost cAMP signaling, suggesting a molecular pathway for the drug's fast-acting antidepressant effects.
Thalamocortical Connectivity and Immune Dysregulation Linked to Suicidal Ideation in Depression
Researchers identify a caudal temporal thalamus network and peripheral gene expression patterns that distinguish suicidal risk in patients.
Activity Modality and Social Context Alter Pediatric Brain Structure
A longitudinal study of 8,230 children links physical-social engagement to increased frontoparietal volume and lower psychiatric risk.
Preclinical Review Links Kratom to Epigenetic Changes and Cardiac Risks
Systematic analysis of 20 studies identifies HDAC2 and Rab35 as markers of dependence while highlighting CYP450 and ion channel interference.
Blood-Brain Barrier Integrity Dictates Serum GFAP Accuracy in Cognitive Impairment
A study of 74 patients shows that serum biomarkers only strongly correlate with central pathology when the blood-brain barrier is disrupted.