Translational Psychiatry
Cohort Study
C4A Complement Pathway Decouples from C1Q in First-Episode Psychosis
A study of 113 patients shows that C4A levels shift independently of C4B in the cerebrospinal fluid during early-stage psychosis.
Translational Psychiatry
Cohort Study
Exogenous Hormones Associate With Reduced Dementia Risk in UK Biobank Cohort
Use of oral contraceptives and hormone replacement therapy correlates with lower rates of Alzheimer's disease and vascular dementia.
Translational Psychiatry
Diagnostic Accuracy Study
Plasma p-tau217 Assays Show High Specificity for Alzheimer’s Diagnosis
Three diverse assay technologies demonstrate 100% specificity in differentiating Alzheimer’s from vascular and frontotemporal dementias.
Translational Psychiatry
Cohort Study
MTOR Hyperactivation Suppresses Autophagy and Drives Neuroinflammation in Schizophrenia
Restoring cellular waste clearance via mTOR inhibition reduces pro-inflammatory cytokines and glial activation in schizophrenia models.
Translational Psychiatry
Animal Study
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.