CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.
Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
Magnetic Seizure Therapy Limits Memory Loss in Bipolar Depression Trial
A randomized pilot study shows magnetic seizure therapy matches the efficacy of ultrabrief ECT while reducing cognitive adverse effects.
Twice-Daily Clobetasol 0.05% Reduces Postoperative Inflammation and Pain
Phase 3 trial data show clobetasol propionate ophthalmic suspension achieves high rates of cell clearance without elevating ocular pressure.
Digital Therapeutic App Reduces Chronic Tinnitus Distress in Randomized Trial
A mobile application delivering cognitive behavioral therapy significantly improved Tinnitus Handicap Inventory scores over 24 weeks.
Ivermectin Fails to Improve Outcomes in Hospitalized COVID-19 Patients
A randomized trial shows no benefit for organ support-free days or survival in critically and noncritically ill patients.
Robotic Kidney Transplant Reduces Complication Rates in Randomized Trial
A Danish study finds robot-assisted surgery lowers major and vascular complications by approximately 10 percent compared to open surgery.
Strengthening and Stretching Yield Similar Quality of Life Gains in Hip Impingement
A randomized trial finds targeted strengthening improves pain perception and muscle force more than stretching, despite equal quality of life scores.
Individualized Algorithm Lowers Achilles Rerupture Risk and Limits Unnecessary Surgery
The CARTA protocol uses ultrasound criteria to select patients for surgery, reducing reruptures by 73% compared to non-operative management.
Higher Ivermectin Dose Does Not Improve Severe Scabies Cure Rates
A randomized trial shows 400 μg/kg of ivermectin plus permethrin is not superior to the standard 200 μg/kg dose for crusted scabies.
Ketamine Shows No Sustained Hemodynamic Advantage Over Propofol During Intubation
A randomized trial in critically ill patients found that ketamine-induced blood pressure benefits were transient and did not improve survival.
MRNA Influenza Vaccine Reduces Infection Risk in Adults Over 50
A phase 3 trial found mRNA-1010 superior to standard vaccines, though it caused more frequent transient systemic reactions.