New England Journal of Medicine
32 articles tagged "New England Journal of Medicine"
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Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
Ensitrelvir Reduces COVID-19 Incidence by 6.1% in Household Contacts
An oral SARS-CoV-2 3C-like protease inhibitor significantly lowers infection rates when given as postexposure prophylaxis.
Telitacicept Reduces Proteinuria in IgA Nephropathy: Phase 3 Interim Analysis
A dual BAFF and APRIL antagonist significantly lowers urinary protein-to-creatinine ratio in adults with IgA nephropathy at high risk of progression.
Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults
Daraxonrasib Shows Activity in Previously Treated RAS-Mutated Pancreatic Cancer
A phase 1-2 study finds that a multiselective RAS inhibitor achieves objective responses and manageable toxicity in advanced disease.
Higher Ivermectin Dose Does Not Improve Severe Scabies Cure Rates
A randomized trial shows 400 μg/kg of ivermectin plus permethrin is not superior to the standard 200 μg/kg dose for crusted scabies.
MRNA Influenza Vaccine Reduces Infection Risk in Adults Over 50
A phase 3 trial found mRNA-1010 superior to standard vaccines, though it caused more frequent transient systemic reactions.
Base Editing of Gamma-Globin Promoters Increases Fetal Hemoglobin in Sickle Cell Disease
Interim phase 1-2 data show risto-cel achieves 60% fetal hemoglobin and eliminates severe vaso-occlusive crises in 31 patients.
Elective Microaxial Flow Pump Does Not Improve High-Risk PCI Outcomes
A randomized trial finds no clinical benefit and a potential mortality signal with routine mechanical unloading during complex revascularization.
Microaxial Flow Pump Fails to Improve Outcomes in High-Risk PCI
A randomized trial of 300 patients shows elective left ventricular unloading does not reduce major adverse events at 12 months.
APT-Sepsis Program Lowers Maternal Infection Mortality and Morbidity
A cluster-randomized trial of 431,394 women shows a 32% reduction in severe infection-related outcomes using a standardized care bundle.
MiniDock MTB Swab Test Meets WHO Accuracy Targets for Tuberculosis
A prospective study of 1380 patients shows tongue and sputum swabs provide accurate molecular detection of pulmonary tuberculosis.