Neuroimaging Biotypes May Guide MDD Treatment, Improve Remission
Functional MRI-derived circuit profiles could personalize major depressive disorder therapy, potentially doubling remission rates.
Three Genetic Loci Modify Risk and Onset of Inherited Alzheimer's Disease
Specific genetic variants influence disease risk and age of dementia onset in autosomal dominant Alzheimer's disease.
Cerebellar Disinhibitory Circuit Controls Motor Learning Signals
New research in mice reveals how synchronized climbing fiber activity selectively gates error signals to enable adaptive motor learning.
Secreted GPNMB Drives Alpha-Synuclein Spread in Parkinson's Disease
A new study identifies a microglial-neuronal feedback loop involving GPNMB that exacerbates alpha-synuclein pathology, offering a therapeutic target.
Skin Biopsy Distinguishes Body-First from Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein signatures and seeding activity identify divergent pathological origins and autonomic denervation patterns.
TES Criteria Show Low Accuracy for CTE-NC Diagnosis
A study of 1,038 brain bank cases reveals that traumatic encephalopathy syndrome criteria poorly predict postmortem chronic traumatic encephalopathy.
Intracranial Stimulation Prevents Attentional Lapses in Children
A new study identifies a real-time neural signature for attentional control, enabling targeted intervention to improve attention shifts.
Recent Trauma Exposure Linked to Increased V1 Thickness, Independent of PTSD Symptoms
A two-sample study identifies greater V1 thickness in recently trauma-exposed individuals, a finding distinct from PTSD symptom severity.
Hippocampal Lesions Reduce Visual Working Memory Precision in Epilepsy Patients
Postoperative hippocampal damage selectively degrades memory quality rather than quantity, offering a marker for functional monitoring.
Reduced ULK1 Links Impaired Cellular Clearance to Alzheimer's Pathology
Lower levels of ULK1 correlate with Alzheimer's disease, and its upregulation improves pathology and cognition in animal models.
Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.
Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.